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Environmental tobacco smoke (ETS) and respiratory health in children

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Abstract

Environmental tobacco smoke (ETS) is a major risk factor for poor lung health in children. Although parental smoking is the commonest source of ETS exposure to children, they are also exposed to ETS in schools, restaurants, public places and public transport vehicles. Apart from containing thousands of chemicals, the particle size in the ETS is much smaller than the main stream smoke, and therefore has a greater penetrability in the airways of children. Exposure to ETS has been shown to be associated with increased prevalence of upper respiratory tract infections, wheeze, asthma and lower respiratory tract infections. Even developing fetuses are exposed to ETS via the umbilical cord blood if the mother is exposed to tobacco smoke. The placenta also does not offer any barrier to the penetration of ETS into the fetus. The immune system in these babies is more deviated toward the allergic and asthmatic inflammatory phenotype and therefore makes them more prone to develop asthma later in life. An increased awareness of the harmful effects of ETS on children's health is warranted.

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References

  1. Adair-Bischoff CE, Sauve RS (1998) Environmental tobacco smoke and middle ear disease in preschool-age children. Arch Pediatr Adolesc Med 152:127–133

    PubMed  CAS  Google Scholar 

  2. Al Mamun A, O’Callaghan FV, Alati R et al (2006) Does maternal smoking during pregnancy predict the smoking patterns of young adult offspring? A birth cohort study. Tob Control 15(6):452–457

    Article  PubMed  Google Scholar 

  3. Babu KS, Arshad SH (2003) The role of allergy in the development of airway inflammation in children. Paediatr Respir Rev 4:40–46

    Article  PubMed  Google Scholar 

  4. Besaratinia A, Pfeifer GP (2008) Second-hand smoke and human lung cancer. Lancet Oncol 9(7):657–666

    Article  PubMed  CAS  Google Scholar 

  5. Blizzard L, Ponsonby A-L, Dwyer T (2003) Parental smoking and infant respiratory infection: how important is not smoking in the same room with the baby? Am J Public Health 93:482–488

    Article  PubMed  Google Scholar 

  6. Brown RW, Hanrahan JP, Castile RG, Tager IB (1995) Effect of maternal smoking during pregnancy on passive respiratory mechanics in early infancy. Pediatr Pulmonol 19:23–28

    Article  PubMed  CAS  Google Scholar 

  7. Boffetta P, Tredaniel J, Greco A (2000) Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: a meta-analysis. Environ Health Perspect 108(1):73–82

    Article  PubMed  CAS  Google Scholar 

  8. Burr ML (1999) Indoor air pollution and the respiratory health of children. Pediatr Pulmonol Suppl 18:3–5

    Article  PubMed  CAS  Google Scholar 

  9. Cnattingius S (2004) The epidemiology of smoking during pregnancy: Smoking prevalence, maternal characteristics, and pregnancy outcomes. Nicotine Tob Res 6:S125–140

    Article  PubMed  Google Scholar 

  10. Castellazzi AM, Maccario R, Moretta A (1999) Effect of active and passive smoking during pregnancy on natural killer-cell activity in infants. J Allergy Clin Immunol 103:172–173

    Article  PubMed  CAS  Google Scholar 

  11. Chen Y, Rennie DC, Dosman JA (1996) Influence of environmental tobacco smoke on asthma in nonallergic and allergic children. Epidemiology 7:536–539

    Article  PubMed  CAS  Google Scholar 

  12. Cook DG, Strachan DP (1998) Parental smoking, bronchial reactivity and peak flow variability in children. Thorax 53(4):295–301

    PubMed  CAS  Google Scholar 

  13. Cook DG, Strachan DP, Carey IM (1998) Parental smoking and spirometric indices in children. Thorax 53:884–893

    PubMed  CAS  Google Scholar 

  14. Cunningham J, Dockery DW, Speizer FE (1994) Maternal smoking during pregnancy as a predictor of lung function in children. Am J Epidemiol 139(12):1139–1152

    PubMed  CAS  Google Scholar 

  15. Doll R, Peto R, Wheatley K et al (1994) Mortality in relation to smoking: 40 years' observations on male British doctors. Br Med J 309:901–911

    CAS  Google Scholar 

  16. Eskenazi B, Castorina R (1999) Association of prenatal maternal or postnatal child environmental tobacco smokes exposure and neurodevelopmental and behavioral problems in children. Environ Health Perspect 107(12):991–1000

    PubMed  CAS  Google Scholar 

  17. Eskenazi B, Trupin LS (1995) Passive and active maternal smoking during pregnancy, as measured by serum cotinine, and postnatal smoke exposure. II. Effects on neurodevelopment at age 5 years. Am J Epidemiol 142(9):S19–S29

    PubMed  CAS  Google Scholar 

  18. Eskenazi B, Bergmann JJ (1995) Passive and maternal active smoking during pregnancy, as measured by serum continine, and postnatal smoke exposure. 1. Effects on physical growth at age 5 years. Am J Epidemiol 142(9):S10–S18

    PubMed  CAS  Google Scholar 

  19. Ey JL, Holberg CJ, Aldous MB (1995) Passive smoking exposure and otitis media in the first year of life. Pediatrics 95:670–677

    PubMed  CAS  Google Scholar 

  20. Frazer-Abel AA, Baksh S, Fosmire SP (2004) Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 311:758–769

    Article  PubMed  CAS  Google Scholar 

  21. Fryer AA, Jones PW (1999) Chapter 22. Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer. IARC Scientific Publications. 303–322.

  22. Gergen PJ, Fowler JA, Maurer KR et al (1998) The burden of environmental tobacco smoke exposure on the respiratory health of children 2 months through 5 years of age in the United States: Third National Health and Nutrition Examination Survey, 1988 to 1994. Pediatrics 101:8–13

    Article  Google Scholar 

  23. Gilliland FD, Berhane K, McConnell R et al (2000) Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 55:271–276

    Article  PubMed  CAS  Google Scholar 

  24. Gilliland FD, Berhane K, Li YF, Rappaport EB et al (2003) Effects of Early onset asthma and in utero exposure to maternal smoking on childhood lung function. Am J Respir Crit Care Med 167:917–924

    Article  PubMed  Google Scholar 

  25. Gilliland FD, Li YF, Dubeau L et al (2002) Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 166:457–463

    Article  PubMed  Google Scholar 

  26. Gilliland FD, Li YF, Peter JM (2001) Effect of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 163:429–36

    PubMed  CAS  Google Scholar 

  27. Goksör E, Amark M, Alm B (2007) The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. Acta Paediatr 96:1030–5

    Article  PubMed  Google Scholar 

  28. Gold DR, Burge HA, Carey V (1999) Predictors of repeated wheeze in the first year of life: the relative role of cockroach, birth weight, acute lower respiratory illness, and maternal smoking. Am J Respir Crit Care Med 160(1):227–236

    PubMed  CAS  Google Scholar 

  29. Gurkan F, Kiral A, Dagli E, Karakoc F (2000) The effect of passive smoking on the development of respiratory syncytial virus bronchiolitis. Eur J Epidemiol 16(5):465–468

    Article  PubMed  CAS  Google Scholar 

  30. Haglund B, Cnattingius S, Otterblad-Olausson P (1995) Sudden infant death syndrome in Sweden, 1983–1990: season at death, age at death, and maternal smoking. Am J Epidemiol 142:619–624

    PubMed  CAS  Google Scholar 

  31. Hanrahan JP, Tager IB, Segal MR et al (1992) The effect of maternal smoking during pregnancy on early lung function. Am Rev Respir Dis 145:1129–1135

    PubMed  CAS  Google Scholar 

  32. Hayes JD, Strange RC (2000) Glutathione s-transferase polymorphisms and their biological consequences. Pharmacology 61:154–166

    Article  PubMed  CAS  Google Scholar 

  33. Hugg TT, Ms Jaakkola, Ruotsalainen RO et al (2007) Parental smoking behaviour and effects of tobacco smoke on children’s health in Finland and Russia. Eur J Public Health 18:55–62

    Article  PubMed  Google Scholar 

  34. Iyengar GV, Rapp A (2001) Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements. Part 3: toxic trace elements in placenta and placenta as a biomarker for these elements. Sci Total Environ 280:221–238

    Article  PubMed  CAS  Google Scholar 

  35. Jaakkola MS (2000) Environmental tobacco smoke and respiratory diseases. In: Annesi-Maesano I, Gulsvik A, Viegi G (eds) Respiratory Epidemiology in Europe. Eur Respir Mono. 15: 322–383.

  36. Jaakkola JJ, Jaakkola MS (2002) Effects of environmental tobacco smoke on the respiratory health of children. Scand J Work Environ Health 28:71–83

    PubMed  Google Scholar 

  37. Jaakkola JJ, Gissler M (2004) Maternal smoking in pregnancy, fetal development, and childhood asthma. Am J Public Health 94(1):136–140

    Article  PubMed  Google Scholar 

  38. Jaakkola JJ, Kosheleva AA, Katsnelson BA (2006) Prenatal and postnatal tobacco smoke exposure and respiratory health in Russian children. Respir Res 7:48

    Article  PubMed  CAS  Google Scholar 

  39. Jaakkola JJ, Nafstad P, Magnus P (2001) Environmental tobacco smoke, parental atopy, and childhood asthma. Environ Health Perspect 109(6):579–582

    Article  PubMed  CAS  Google Scholar 

  40. Jedrychowski W, Flak E (1997) Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infection. Environ Health Prospect 105(3):302–6

    Article  CAS  Google Scholar 

  41. Jindal SK, Gupta D (2004) The relationship between tobacco smoke & bronchial asthma. Indian J Med Res 120:443–453

    PubMed  CAS  Google Scholar 

  42. Jinot J, Bayard SP (1994) Respiratory health effects of passive smoking: EPA’s weight-of-evidence analysis. Clin Epidemiol 47:339–349

    Article  CAS  Google Scholar 

  43. Johansson A, Ludvigsson J, Hermansson G (2008) Adverse health effects related to tobacco smoke exposure in a cohort of three-year olds. Acta Paediatr 97:354–357

    Article  PubMed  Google Scholar 

  44. Jauniaux E, Gulbis B, Acharya G, Thiry P, Rodeck C (1999) Maternal tobacco exposure and cotinine levels in fetal fluids in the first half of pregnancy. Obstet Gynecol 93(1):25–9

    Article  PubMed  CAS  Google Scholar 

  45. Kabesch M, Hoefler C, Carr D et al (2004) Glutathione S transferase deficiency and passive smoking increase childhood asthma. Thorax 59:569–573

    Article  PubMed  CAS  Google Scholar 

  46. Keskinoglu P, Cimrin D, Aksakoglu G (2007) The impact of passive smoking on the development of lower respiratory tract infections in children. J Trop Pediatr 53(3):569–573. doi:10.1093

    Google Scholar 

  47. Keskinoglu P, Cimrin D, Aksakoglu G (2007) Relationships between cotinine, lower respiratory tract infection, and eosinophil cationic protein in children. Eur J Pediatr 166(5):455–9

    Article  PubMed  CAS  Google Scholar 

  48. Klonoff-Cohen HS, Edelstein SL, Lefkowitz ES (1995) The effect of passive smoking and tobacco exposure through breast milk on sudden infant death syndrome. JAMA 273(10):795–798

    Article  PubMed  CAS  Google Scholar 

  49. Knight JM, Eliopoulos C, Klein J (1998) Pharmacokinetic predisposition to nicotine from environmental tobacco smoke: a risk factor for pediatric asthma. J Asthma 3:113–117

    Article  Google Scholar 

  50. Ph Kum-Nji, Meloy L, Herrod HG (2006) Environmental tobacco smoke exposure: prevalence and mechanisms of causation of infections in children. Pediatrics 117(5):1745–1754

    Article  Google Scholar 

  51. Lacayo CI, Pak W, Benowitz NL et al (2001) Transport and disposition of nicotine in the human placenta. Clin Pharmacol Ther 69:P95

    Google Scholar 

  52. Lambers DS, Clark KE (1996) The maternal and fetal physiologic effects of nicotine. Semin Perinatol 20(2):115–26

    Article  PubMed  CAS  Google Scholar 

  53. Lanari M, Giovannini M, Giuffre L et al (2002) Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity. Pediatr Pulmonol 33(6):458–465

    Article  PubMed  CAS  Google Scholar 

  54. Landrigen PJ, Carlson JE (1995) Environmental policy & children’s health. Future Child 5(2):34–52

    Article  Google Scholar 

  55. Larsson ML, Frisk M, Hallstrom J (2001) Environmental tobacco smoke exposure during childhood is associated with increased prevalence of asthma in adults. Chest 120(3):711–717

    Article  PubMed  CAS  Google Scholar 

  56. Law BJ, Carbonell-Estrany X, Simoes EA (2002) An update on respiratory syncytial virus epidemiology: a developed country perspective. Respir Med 96:S1–S7

    PubMed  Google Scholar 

  57. Lee W, Galant S (2002) Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Pediatrics 110(2):445–446

    Google Scholar 

  58. Lewis S, Richards D, Bynner J (1995) Prospective study of risk factors for early and persistent wheezing in childhood. Eur Respir J 8:349–356

    Article  PubMed  CAS  Google Scholar 

  59. Lichtensteiger W, Ribary U, Schlumpf M (1988) Prenatal adverse effects of nicotine on the developing brain. Prog Brain Res 73:137–157

    Article  PubMed  CAS  Google Scholar 

  60. Li YF, Langholz B, Salam TM, Gilliland FD (2005) Maternal and grand maternal smoking patterns are associated with early childhood asthma. Chest 127:1232–1241

    Article  PubMed  Google Scholar 

  61. Lindbohm M-L, Sallmén M, Taskinen H (2002) Effects of exposure to environmental tobacco smoke on reproductive health. Scand J Work Environ Health 28(2):84–96

    PubMed  CAS  Google Scholar 

  62. Majeed R, Rajar U, Shaikh N (2008) Risk factors associated with childhood asthma. JCPSP 18(5):299–302

    PubMed  Google Scholar 

  63. Mannino DM, Moorman JE, Kingsley B et al (2001) Health effects related to environmental tobacco smoke exposure in children in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 155:36–41

    PubMed  CAS  Google Scholar 

  64. Manuel JS (2000) Sins of the father: parental smoking and childhood cancer. Environ Health Perspect 108(1):A30–A31

    Article  PubMed  CAS  Google Scholar 

  65. Martinez FD, Wright AL, Holberg CJ et al (1992) Maternal age as a risk factor for wheezing lower respiratory illnesses in the first year of life. Am J Epidemiol 136:1258–1268

    PubMed  CAS  Google Scholar 

  66. Melen E, Wickman M, Nordvall SL (2001) Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children. Allergy 56(7):646–652

    Article  PubMed  CAS  Google Scholar 

  67. Message SD, Johnston SL (2002) The role of viruses in childhood respiratory infections. Br Med Bull 61(1):29–43

    Article  PubMed  Google Scholar 

  68. Mishra V, Smith KR, Retherford RD (2005) Effects of cooking smoke and environmental tobacco smoke on acute respiratory infections in young Indian children. Popul Environ 26(5):375–396

    Article  Google Scholar 

  69. Mitchell EA, Ford RP, Stewart AW, Thompson JM, Scragg R, Hassall IB, Barry DM, Allen EM (1993) Smoking and the sudden infant death syndrome. Pediatrics 91(5):893–896

    PubMed  CAS  Google Scholar 

  70. Moore ML, Zaccaro DL (2000) Cigarette smoking, low birth weight and preterm births in low-income African American women. J Perinatol 20(3):176–180

    Article  PubMed  CAS  Google Scholar 

  71. Moshammer H, Hoek G, Luttmann-Gibson H (2006) Parental smoking and lung function in children: an international study. Am J Respir Crit Care Med 173:1255–1263

    Article  PubMed  Google Scholar 

  72. Moya J, Bearer CF, Etzel RA (2004) Children’s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 113(4):996–1006

    PubMed  Google Scholar 

  73. Mucci LA, Granath F, Cnattingius S (2004) Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. Cancer Epidemiol Biomark Prev 13:1528–1533

    CAS  Google Scholar 

  74. Nafstad P, Kongerud J, Botten G (1997) The role of passive smoking in the development of bronchial obstruction during the first 2 years of life. Epidemiology 8:293–297

    Article  PubMed  CAS  Google Scholar 

  75. Nanavaty U, Goldstein AD, Levine SJ (2001) Polymorphisms in candidate asthma genes. Am J Med Sci 321:11–16

    Article  PubMed  CAS  Google Scholar 

  76. Numabe Y, Ogawa T, Kamoi H et al (1998) Phagocytic function of salivary PMN after smoking or secondary smoking. Ann Periodontol 3:102–107

    PubMed  CAS  Google Scholar 

  77. Nuorti JP, Butler JC, Farley MM (2000) Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team. N Engl J Med 34(10):681–689

    Article  Google Scholar 

  78. O’Dempsey TJD, McArdle TF, Morris J et al (1996) A study of risk factors for pneumococcal disease among children in a rural area of West Africa. Int J Epidemiol 25(4):885–693

    Article  PubMed  Google Scholar 

  79. Office of Environmental Health Hazard Assessment California Environmental Protection Agency (2005) Health effects assessment for environmental tobacco smoke. Available from: ftp://ftp.arb.ca.gov/carbis/regact/ets2006/app3part%20b.pdf

  80. Pabst MJ, Pabst KM, Collier JA (1995) Inhibition of neutrophil and monocyte defensive functions by nicotine. J Periodontol 66:1047–1055

    PubMed  CAS  Google Scholar 

  81. Palmer CN, Doney AS, Lee SP et al (2006) Glutathione S-transferase M1 and P1 genotype. passive smoking, and peak expiratory flow in asthma. Pediatrics 118:710–6

    Article  PubMed  Google Scholar 

  82. Pattenden S, Antova, Neuberger M (2006) Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure. Tob Control 15:294–301

    Article  PubMed  Google Scholar 

  83. Peto R, Lopez AD, Boreham J et al (1994) Mortality from smoking in developed countries 1950–2000: indirect estimates from National Vital Statistics. Oxford University Press, Oxford

    Google Scholar 

  84. Rice D, Barone S (2000) Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108:511–33

    Article  PubMed  Google Scholar 

  85. Roth MD, Whittaker K, Salehi K et al (2004) Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers. J Neuroimmunol 147:82–86

    Article  PubMed  CAS  Google Scholar 

  86. Rudell B, Blomberg A, Helleday R et al (1999) Bronchoalveolar inflammation after exposure to diesel exhaust: comparison between unfiltered and particle trap filtered exhaust. Occup Environ Med 56:527–534

    Article  PubMed  CAS  Google Scholar 

  87. Rylander R, Megevand Y (2000) Environmental risk factors for respiratory infections. Arch Environ Health 55(5):300–3

    PubMed  CAS  Google Scholar 

  88. Sasco AJ, Vainio H (1999) From in utero and childhood exposure to parental smoking to childhood cancer: a possible link and the need for action. Human Exp Toxicol 18(4):192–201

    Article  CAS  Google Scholar 

  89. Schwartz J, Timonen K, Pekkanen J (2000) Respiratory effects of environmental tobacco smoke in a panel study of asthmatic and symptomatic children. Am J Respir Crit Care Med 161:802–806

    PubMed  CAS  Google Scholar 

  90. Seeman JI, Carchman RA (2008) The possible role of ammonia toxicity on the exposure, deposition, retention, and the bioavailability of nicotine during smoking. Food Chem Toxicol 46(6):1863–1881

    Article  PubMed  CAS  Google Scholar 

  91. Seymour BW, Pinkerton KE, Friebertshauser KE (1997) Second-hand smoke is an adjuvant for T helper-2 responses in a murine model of allergy. J Immunol 159:6169–6175

    PubMed  CAS  Google Scholar 

  92. Sheikh S, Goldsmithl J, Howell L et al (1999) Comparison of lung function in infants exposed to maternal smoking and in infants with a family history of asthma. Chest 16(1):52–58

    Article  Google Scholar 

  93. Shields PG, Harris CC (2000) Cancer risk and low-penetrance susceptibility genes in gene–environment interactions. J Clin Oncol 18:2309–2315

    PubMed  CAS  Google Scholar 

  94. Shiono PH, Klebanoff MA, Berendes HW (2005) Epidemiology congenital malformations and maternal smoking during pregnancy. Teratology 34(1):65–71

    Article  Google Scholar 

  95. Spitzer WO, Lawrence V, Dales R et al (1990) Links between passive smoking and disease: a best evidence synthesis. A report of the working group on passive smoking. Clin Invest Med 13(1):17–42

    PubMed  CAS  Google Scholar 

  96. Stanwell-Smith RE, Stuart JM, Hughes AO et al (1994) Smoking, the environment and meningococcal disease: a case control study. Epidemiol Infect 112(2):315–328

    Article  PubMed  CAS  Google Scholar 

  97. Stein RT, Holberg CJ, Sherrill D (1999) Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children’s Respiratory Study. Am J Epidemiol 149(11):1030–1037

    PubMed  CAS  Google Scholar 

  98. Stick SM, Burton PR, Gurrin L et al (1996) Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet 348:1060–1064

    Article  PubMed  CAS  Google Scholar 

  99. Stillman F, Navas-Acien A, Ma J et al (2007) Second-hand tobacco smoke in public places in urban and rural China. Tob Control 16(4):229–34

    Article  PubMed  Google Scholar 

  100. Strachan DP, Cook DG (1998) Health effects of passive smoking. 5. Parental smoking and allergic desensitization in children. Thorax 53:117–123

    Article  PubMed  CAS  Google Scholar 

  101. Strachan DP, Cook DG (1997) Health effects of passive smoking. 1. Parental smoking and lower respiratory illness in infancy and early childhood. Thorax 52:905–914

    PubMed  CAS  Google Scholar 

  102. Suarez-Varela MM, Gonzalez AL, Martinez Selva MI (1999) Socioeconomic risk factors in the prevalence of asthma and other atopic diseases in children 6 to 7 years old in Valencia Spain. Eur J Epidemiol 15:35–40

    Article  PubMed  CAS  Google Scholar 

  103. Tamburlini G, von Ehrenstein OS, Bertollini R (2002) Children’s health and environment: a review of evidence. A joint report from the European Environment Agency and the WHO Regional Office for Europe.

  104. Tager IB, Hanrahan JP, Tosteson TD et al (1993) Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. Am Rev Respir Dis 147:811–817

    PubMed  CAS  Google Scholar 

  105. US Department of Health and Human Services (2004) The health consequences of involuntary smoking. A report of the surgeon general. Atlanta, DC, (DHHS Pub. No. (PHS) 87-8398).

  106. US Environmental Protection Agency (1992) Respiratory health effects of passive smoking: lung cancer and other disorders. Washington, DC, (EPA/600/6-90/006F).

  107. Vahidnia F, Eskenazi B, Jewell N (2008) Maternal smoking, alcohol drinking, and febrile convulsion. Seizure 17(4):320–6

    Article  PubMed  Google Scholar 

  108. Vardavas CI, Tzatzarakis MN, Tsatsakis AM et al (2006) Biomarkers of passive smoking among Greek preschool children. Eur J Pediatr 165(12):891–6

    Article  PubMed  CAS  Google Scholar 

  109. Brower Vicki (2006) World Health Organization focuses on antitobacco efforts in developing nations through treaty. JNCI 98(10):667–668

    PubMed  Google Scholar 

  110. Vork KL, Broadwin RL, Blaisdell RJ (2007) Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression. Environ Health Perspect 115(10):1394–1400

    PubMed  Google Scholar 

  111. Warren CW, Jones NR, Peruga A et al (2008) Global tobacco is youth tobacco surveillance, 2000–2007, MMWR. 57(sso1)1–2.

  112. Weiss ST (1999) Gene by environment interaction and asthma. Clin Exp Allergy 29:96–99

    Article  PubMed  Google Scholar 

  113. Weitzman M, Gortmaker S, Sobol A (1992) Maternal smoking and behavior problems of children. Pediatrics 90(3):342–349

    PubMed  CAS  Google Scholar 

  114. Wisborg K, Kesmodel U, Henriksen TB (2000) A prospective study of smoking during pregnancy and SIDS. Arch Dis Child 83(3):203–206

    Article  PubMed  CAS  Google Scholar 

  115. Wu FY, Chiu HT, Wu HDI et al (2008) Comparison of urinary and plasma cotinine levels during the three trimesters of pregnancy. Paediatr Perinat Epidemiol 22:296–301

    Article  PubMed  Google Scholar 

  116. Young S, Le Souef PN, Geelhoed GC (1991) The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. N Engl J Med 324:1168–1173

    Article  PubMed  CAS  Google Scholar 

  117. Zhang S, Petro TM (1996) The effect of nicotine on murine CD4 T cell responses. Int J Immunopharmacol 18:467–478

    Article  PubMed  CAS  Google Scholar 

  118. Zlotkwaska R, Zejda J (2005) Fetal and postnatal exposure to tobacco smoke and respiratory health in children. Eur J Epidemiol 20(8):719–727

    Article  Google Scholar 

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  1. School of Health Sciences, University of Pune, Pune, India

    Maria Cheraghi

  2. Chest Research Foundation, Marigold, Kalyaninagar, Pune, 411014, India

    Maria Cheraghi & Sundeep Salvi

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Cheraghi, M., Salvi, S. Environmental tobacco smoke (ETS) and respiratory health in children. Eur J Pediatr 168, 897–905 (2009). https://doi.org/10.1007/s00431-009-0967-3

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