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Impact of high myopia on the performance of SD-OCT parameters to detect glaucoma

  • Glaucoma
  • Published:
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Abstract

Background

The aim was to evaluate the effects of high myopia on spectral-domain optical coherence tomography (SD-OCT) parameters, as well as on their ability to detect glaucoma.

Methods

Ninety-three glaucoma and 86 non-glaucoma patients were divided into highly myopic group (HMG; 90 subjects, ≤ −5 diopters [D]) and emmetropic (EG; 89 subjects, spherical equivalent ≤1 D and ≥ −1D) groups in this cross-sectional comparative study. Macular ganglion cell complex (GCC) and circumpapillary retinal nerve fiber layer (cpRNFL) measurements obtained from the algorithms of the SD-OCT system were compared. The effects of refractive errors and glaucoma were assessed using a generalized linear model, after adjusting for age. A receiver operating characteristic curve was constructed for each parameter, and the areas under the curves (AUCs) were compared.

Results

The all cpRNFL measurements were significantly related to both refractive errors and glaucoma, while all GCC parameters were not significantly related to the refractive errors. The AUC for average GCC thickness was similar between the HMG (AUC, 0.935) and EG (AUC, 0.933), while the AUC for average cpRNFL thickness differed significantly (p = 0.028) between the HMG (AUC, 0.827) and EG (AUC, 0.939).

Conclusions

Macular GCC parameters showed good ability to detect glaucoma in both groups, whereas the ability of cpRNFL measurement in HMG subjects was inferior to that in EG subjects. Assessment of GCC parameters is a useful technique complementary to cpRNFL thickness assessment, for clinically evaluating patients with concomitant glaucoma and high myopia.

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Acknowledgments

Funding/support and financial disclosures

The authors received no financial support, and declare that they have no financial conflicts of interest.

Contributions of authors

Designing and conducting the study (T.S., E.C.); collection, management, analysis, and interpretation of data (T.S., Y.N., H.S., E.C.); preparation of manuscript (T.S.); and review and approval of the manuscript (H.S., E.C.).

Conflicts of interest

The authors have no proprietary interest in any aspect of this study. The authors report no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Yukisada Hospital, Kawagoe, Saitama, Japan

    Takuhei Shoji

  2. Sensho-kai Eye Institute, Uji, Kyoto, Japan

    Yui Nagaoka & Etsuo Chihara

  3. Department of Medical Informatics, National Defense Medical College Hospital, Tokorozawa, Saitama, Japan

    Hiroki Sato

  4. Department of Ophthalmology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Takuhei Shoji

Authors
  1. Takuhei Shoji
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  2. Yui Nagaoka
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  3. Hiroki Sato
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  4. Etsuo Chihara
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Corresponding author

Correspondence to Takuhei Shoji.

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Shoji, T., Nagaoka, Y., Sato, H. et al. Impact of high myopia on the performance of SD-OCT parameters to detect glaucoma. Graefes Arch Clin Exp Ophthalmol 250, 1843–1849 (2012). https://doi.org/10.1007/s00417-012-1994-8

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  • DOI: https://doi.org/10.1007/s00417-012-1994-8

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