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Heart failure in acute ischemic stroke

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Abstract

Background

To determine the impact of heart failure (HF), with preserved or decreased left ventricular function (LVF), on outcome in patients with acute ischemic stroke (AIS).

Methods

We studied 503 unselected ischemic stroke patients. Poor outcome was defined as moderate-severe disability or death at 90 days. We analyzed the association between poor outcome and HF with preserved LVF or decreased LVF (systolic HF: ejection fraction lower than 50%). We tested this association adjusted by possible confounders in a logistic regression model.

Results

89 patients (17.7 %) had HF; 49 patients (9.7%) with systolic HF, and 40 (8%) patients with HF and preserved LVF. HF with preserved LVF patients were older [79.4 (7.9) vs. 74.3 (10.4), p = 0.013],more likely to be women [p < 0.001,OR = 8.61, 95% CI (3.3–22.6)], and with lower current smoking habits [p = 0.018, OR = 8.77 (1.1–72.6)] than patients with systolic HF. 151 patients (30 %) had poor outcome. We found an independent association with initial stroke severity, systolic HF (adjusted OR = 3.01), HF with preserved LVF (adjusted OR = 2.52), thrombolytic treatment, statin pre-treatment (as protectors) and poor outcome.

Conclusion

Both forms of HF (with or without decreased systolic function) are associated with poor outcome in AIS.

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Authors and Affiliations

  1. Unit of Neurovascular Research, Neurology Department, Institut Municipal d'Investigació Mèdica – Hospital del Mar, Departament de Medicina, Universitat Autònoma de Barcelona, Spain

    A. Ois MD, M. Gomis MD, E. Cuadrado-Godia MD, J. Jiménez-Conde MD, A. RodrÍguez-Campello MD & J. Roquer MD PhD

  2. Cardiology department, Hospital del Mar, Barcelona, Spain

    J. Bruguera MD, L. Molina MD, PhD & J. Comin MD

  3. Servicio de NeurologÍa, Hospital del Mar, Passeig Maritim 25–29, 08003, Barcelona, Spain

    A. Ois MD

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  1. A. Ois MD
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  2. M. Gomis MD
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  3. E. Cuadrado-Godia MD
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  4. J. Jiménez-Conde MD
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  5. A. RodrÍguez-Campello MD
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  7. L. Molina MD, PhD
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  8. J. Comin MD
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  9. J. Roquer MD PhD
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Correspondence to A. Ois MD.

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Ois, A., Gomis, M., Cuadrado-Godia, E. et al. Heart failure in acute ischemic stroke. J Neurol 255, 385–389 (2008). https://doi.org/10.1007/s00415-008-0677-1

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  • DOI: https://doi.org/10.1007/s00415-008-0677-1

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