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Gestational diabetes: a strong independent risk factor for severe neonatal respiratory failure after 34 weeks

  • Materno-fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate if gestational diabetes (GD) exposes neonates delivered after 34 weeks to an increased risk of severe neonatal respiratory failure (NRF).

Methods

Data from 3,237 women who delivered after 34 weeks with systematic screening for GD were analyzed. Diagnosis of severe NRF required the association of clinical and radiological criteria with a minimum of 24 h of ventilation and admission to neonatal intensive care unit.

Results

A total of 166 (5.1%) cases of GD were identified. Severe NRF was diagnosed in 7 (4.21%) cases among women with GD as compared to 13 (0.42%) in others (p < 0.001). The rate of severe NRF was also significantly higher in cases of premature delivery (p < 0.001), fetal growth retardation (p < 0.001), and cesarean section (p = 0.005). After adjustment for these variables, GD was identified as an independent risk factor for NRF (AOR 11.55, 95% CI 3.9–33.9, p < 0.001). Two other risk factors were also identified: late preterm delivery (AOR 6.13, 95% CI 1.8–21.2, p = 0.004); and hypotrophy (AOR 9.16, 95% CI 2.7–30.5, p < 0.001).

Conclusions

GD is an independent risk factor for severe NRF after 34 weeks. Neonates from such pregnancies should be monitored carefully.

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Acknowledgments

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All authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Service de Gynécologie Obstétrique, Hôpital de Pointe-à Pitre Abymes, 97159, Pointe à Pitre Cedex, Guadeloupe, France

    Pauline Vignoles & Eustase Janky

  2. Service de Gynécologie Obstétrique, Hôpital Nord, Chemin des Bourrely, 13915 Cedex 20, Marseille, France

    Pauline Vignoles, Florence Bretelle, Léon Boubli & Xavier Carcopino

  3. Service Santé Publique, Hôpital de la Timone, 264, Rue Saint-Pierre, 13385, Marseille Cedex 5, France

    Julien Mancini

  4. Service de Pédiatrie, Hôpital Nord, Chemin des Bourrely, 13915 Cedex 20, Marseille, France

    Catherine Gire

Authors
  1. Pauline Vignoles
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  2. Catherine Gire
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  3. Julien Mancini
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  4. Florence Bretelle
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  5. Léon Boubli
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  6. Eustase Janky
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  7. Xavier Carcopino
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Corresponding author

Correspondence to Xavier Carcopino.

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Vignoles, P., Gire, C., Mancini, J. et al. Gestational diabetes: a strong independent risk factor for severe neonatal respiratory failure after 34 weeks. Arch Gynecol Obstet 284, 1099–1104 (2011). https://doi.org/10.1007/s00404-010-1810-9

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  • DOI: https://doi.org/10.1007/s00404-010-1810-9

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