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Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

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Abstract

Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.

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Acknowledgments

We thank our colleagues, co-investigators, and collaborators for many relevant observations and discussions and for contributions to work cited in this review. We also thank Jenny Pierce and Diana Lim for invaluable and creative efforts in the preparation of the manuscript and figures. Work cited in this review was supported by the National Institutes of Health (HL044525, HL066277, HL091754, HL092746, HL048872, HL090870, and K231440921), public health service grants ULI-RRO25764 and CO6-RR11234 from the National Center for Research Resources, a Deutsche Forschlungsgemenschaft (DFG) grant (SCHW 1167/1-2), and Western States Affiliate American Heart Association awards 0625098Y and 09BGIA2250381 and by Conselho Nacional de Pesquisa e Desenvolvimento Technológico (CNPq).

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Correspondence to Guy A. Zimmerman.

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This article is published as part of the Special Issue on Coagulation and Inflammation [34:1].

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Vieira-de-Abreu, A., Campbell, R.A., Weyrich, A.S. et al. Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol 34, 5–30 (2012). https://doi.org/10.1007/s00281-011-0286-4

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