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Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness

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Abstract

Temporal summation of muscle pain is an important factor in musculoskeletal pain as central integration of repetitive nociceptive input can be facilitated in musculoskeletal pain patients. The aim of this study is to evaluate changes in temporal summation of pressure pain after induction of delayed onset muscle soreness (DOMS) of the trapezius muscle. Sixteen healthy volunteers participated in the study. Temporal summation of pain was induced by sequential pressure stimulation by a computer-controlled algometer. Sequential stimulation consisting of ten stimuli (at pressure pain threshold intensity) was applied over the trapezius muscle. Stimulus duration was 1 s and inter-stimulus intervals (ISI) were 1, 5, 10, and 30 s, respectively. The pain was rated on a continuous visual analogue scale (VAS, 10 cm) after each stimulus and normalised to the VAS score from the first stimulus. DOMS was induced in the right trapezius muscle by eccentric shoulder exercises while the left trapezius muscle served as control. Temporal summation of pressure evoked pain was measured before and 24 h after the exercise. At 24 h after exercise, soreness intensity during shoulder elevation was 3.7±0.2 cm, while no soreness was observed on the control side. When sequential pressure stimulation was applied to the DOMS muscle, VAS scores for 1 s ISI progressively increased to a higher level than before exercise (VAS increase for the last stimulus: 0.8±0.2 cm vs. 0.6±0.1 cm, P<0.05), while VAS scores for ISI 5, 10, and 30 s were not increased. On the control side, significant increases in VAS scores was observed for all ISIs but not affected by contralateral DOMS. Facilitation of temporal summation for 1 s ISI indicated that DOMS may increase the central excitability besides involving peripheral sensitisation. During DOMS there was no potential for further nociceptor sensitisation by repeated noxious pressure stimuli, which may account for the diminishment of temporal summation evoked by pressure stimuli with ISI 5, 10, and 30 s. These data indicate that muscle soreness might facilitate the central components of temporal summation to mechanical stimulation.

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Acknowledgements

Pfizer Ltd. for the unrestricted educational grant and Norma og Frode S. Jacobsens fund supported this study.

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Authors and Affiliations

  1. Laboratory for Experimental Pain Research, Department of Health Science and Technology, Center for Sensory-Motor Interaction (SMI), Aalborg University, Fredrik Bajers Vej 7D-3, 9220, Aalborg, Denmark

    Hongling Nie, Lars Arendt-Nielsen, Pascal Madeleine & Thomas Graven-Nielsen

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  1. Hongling Nie
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  2. Lars Arendt-Nielsen
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  3. Pascal Madeleine
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  4. Thomas Graven-Nielsen
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Correspondence to Thomas Graven-Nielsen.

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Nie, H., Arendt-Nielsen, L., Madeleine, P. et al. Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness. Exp Brain Res 170, 182–190 (2006). https://doi.org/10.1007/s00221-005-0196-6

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  • DOI: https://doi.org/10.1007/s00221-005-0196-6

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