Septic shock

Efficacy and safety of 1C class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock compared to amiodarone: protocol of a prospective randomised double-blind study
Martin Balik, Petr Waldauf, Michal Maly, Vojtech Matousek, Tomas Brozek, Jan Rulisek, Michal Porizka, Robert Sachl, Michal Otahal, Petr Brestovansky, Eva Svobodova, Marek Flaksa, Zdenek Stach, Jaroslav Pazout, Frantisek Duska, Ondrej Smid, Martin Stritesky

BMJ Open Sep 2019, 9 (9) e031678; DOI: 10.1136/bmjopen-2019-031678
Levosimendan and Global Longitudinal Strain Assessment in Sepsis (GLASSES 1): a study protocol for an observational study
Iacopo Cappellini, Alessandra Melai, Lucia Zamidei, Maddalena Parise, Simone Cipani, Guglielmo Consales

BMJ Open Sep 2020, 10 (9) e037188; DOI: 10.1136/bmjopen-2020-037188
Usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to Sepsis-3 compared with procalcitonin and C reactive protein: a prospective cohort study in China
Yixuan Zhou, Zhen Liu, Jun Huang, Guiling Li, Fengying Li, Yulan Cheng, Xinyou Xie, Jun Zhang

BMJ Open Apr 2019, 9 (4) e026527; DOI: 10.1136/bmjopen-2018-026527
Is haemoglobin below 7.0 g/dL an optimal trigger for allogenic red blood cell transfusion in patients admitted to intensive care units? A meta-analysis and systematic review
Ren-qi Yao, Chao Ren, Zi-cheng Zhang, Yi-bing Zhu, Zhao-fan Xia, Yong-ming Yao

BMJ Open Feb 2020, 10 (2) e030854; DOI: 10.1136/bmjopen-2019-030854
Prospective longitudinal observational study of the macro and micro haemodynamic responses to septic shock in the renal and systemic circulations: a protocol for the MICROSHOCK – RENAL study
Jim Watchorn, Dean Huang, Philip Hopkins, Kate Bramham, Sam Hutchings

BMJ Open Aug 2019, 9 (8) e028364; DOI: 10.1136/bmjopen-2018-028364
Global epidemiology of septic shock: a protocol for a systematic review and meta-analysis
Frank Leonel Tianyi, Joel Noutakdie Tochie, Celestin Danwang, Aime Mbonda, Mazou N Temgoua, Sylvester Yari Mapoh, Njinkeng J Nkemngu, Esther Tallah, Jean Joel Bigna

BMJ Open Nov 2019, 9 (11) e032289; DOI: 10.1136/bmjopen-2019-032289
A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)
Christopher Geven, Alice Blet, Matthijs Kox, Oliver Hartmann, Paul Scigalla, Jens Zimmermann, Gernot Marx, Pierre-François Laterre, Alexandre Mebazaa, Peter Pickkers

BMJ Open Feb 2019, 9 (2) e024475; DOI: 10.1136/bmjopen-2018-024475
Effect of levosimendan on mortality in severe sepsis and septic shock: a meta-analysis of randomised trials
Wei Chang, Jian-Feng Xie, Jing-Yuan Xu, Yi Yang

BMJ Open Mar 2018, 8 (3) e019338; DOI: 10.1136/bmjopen-2017-019338
Multicentre validation of a sepsis prediction algorithm using only vital sign data in the emergency department, general ward and ICU
Qingqing Mao, Melissa Jay, Jana L Hoffman, Jacob Calvert, Christopher Barton, David Shimabukuro, Lisa Shieh, Uli Chettipally, Grant Fletcher, Yaniv Kerem, Yifan Zhou, Ritankar Das

BMJ Open Jan 2018, 8 (1) e017833; DOI: 10.1136/bmjopen-2017-017833
Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?
Joshua L C Wong, Alexina J Mason, Anthony C Gordon, Stephen J Brett

BMJ Open Aug 2018, 8 (8) e020068; DOI: 10.1136/bmjopen-2017-020068

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