Biomarkers

IC3 protocol: a longitudinal observational study of cognition after stroke using novel digital health technology
Dragos-Cristian Gruia, William Trender, Peter Hellyer, Soma Banerjee, Joseph Kwan, Henrik Zetterberg, Adam Hampshire, Fatemeh Geranmayeh

BMJ Open Nov 2023, 13 (11) e076653; DOI: 10.1136/bmjopen-2023-076653
Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic
Gideon B Valstar, Sophie H Bots, Floor Groepenhoff, Aisha Gohar, Frans H Rutten, Tim Leiner, Maarten Jan Maria Cramer, Arco J Teske, Leonardo P Suciadi, Roxana Menken, Gerard Pasterkamp, Folkert W Asselbergs, Leonard Hofstra, Michael L Bots, Hester M den Ruijter

BMJ Open Jun 2019, 9 (6) e028408; DOI: 10.1136/bmjopen-2018-028408
The UroLife study: protocol for a Dutch prospective cohort on lifestyle habits in relation to non-muscle-invasive bladder cancer prognosis and health-related quality of life
Liesbeth de Goeij, Ellen Westhoff, J Alfred Witjes, Katja KH Aben, Ellen Kampman, Lambertus ALM Kiemeney, Alina Vrieling

BMJ Open Oct 2019, 9 (10) e030396; DOI: 10.1136/bmjopen-2019-030396
Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review
Enrico Glaab, Armin Rauschenberger, Rita Banzi, Chiara Gerardi, Paula Garcia, Jacques Demotes

BMJ Open Dec 2021, 11 (12) e053674; DOI: 10.1136/bmjopen-2021-053674
Leg ischaemia management collaboration (LIMb): study protocol for a prospective cohort study at a single UK centre
John S M Houghton, Sarah Nduwayo, Andrew T O Nickinson, Tanya J Payne, Sue Sterland, Mintu Nath, Laura J Gray, Greg S McMahon, Harjeet S Rayt, Sally J Singh, Thompson G Robinson, Simon P Conroy, Victoria J Haunton, Gerry P McCann, Matthew J Bown, Robert S M Davies, Rob D Sayers

BMJ Open Sep 2019, 9 (9) e031257; DOI: 10.1136/bmjopen-2019-031257
Usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to Sepsis-3 compared with procalcitonin and C reactive protein: a prospective cohort study in China
Yixuan Zhou, Zhen Liu, Jun Huang, Guiling Li, Fengying Li, Yulan Cheng, Xinyou Xie, Jun Zhang

BMJ Open Apr 2019, 9 (4) e026527; DOI: 10.1136/bmjopen-2018-026527
Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial
D P Devanand, Howard Andrews, William C Kreisl, Qolamreza Razlighi, Anne Gershon, Yaakov Stern, Akiva Mintz, Thomas Wisniewski, Edward Acosta, Julianna Pollina, Mariasofia Katsikoumbas, Karen L Bell, Gregory H Pelton, Deborah Deliyannides, K M Prasad, Edward D Huey

BMJ Open Feb 2020, 10 (2) e032112; DOI: 10.1136/bmjopen-2019-032112
Use of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women: protocol for a systematic review and meta-analysis
Renato T Souza, Rafael Bessa Galvão, Debora Farias Batista Leite, Renato Passini Jr, Philip Baker, Jose Guilherme Cecatti

BMJ Open Mar 2019, 9 (3) e026033; DOI: 10.1136/bmjopen-2018-026033
Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer’s disease
Ivan Koychev, Jennifer Lawson, Tharani Chessell, Clare Mackay, Roger Gunn, Barbara Sahakian, James B Rowe, Alan J Thomas, Lynn Rochester, Dennis Chan, Brian Tom, Paresh Malhotra, Clive Ballard, Iain Chessell, Craig W Ritchie, Vanessa Raymont, Iracema Leroi, Imre Lengyel, Matt Murray, David L Thomas, John Gallacher, Simon Lovestone

BMJ Open Mar 2019, 9 (3) e024498; DOI: 10.1136/bmjopen-2018-024498
Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
Ulrica Nilsson, Karin Liander, Olav Rooyackers, Lars I Eriksson

BMJ Open Dec 2019, 9 (12) e032650; DOI: 10.1136/bmjopen-2019-032650

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