Table 1

Anaesthesia management data

Panel (A)
				Anaesthesia induction and maintenance
Subject ID	Group	Weight (kg)	Surgery duration (min)	Rocuronium* (mg)	Fentanyl* (µg)	Remifentanil* (µg)	Remifentanil Drip (µg/kg/min)	Propofol* (mg)	Sevoflurane (Y or N)	Desflurane (Y or N)
1	Control	68	321	120	0	772	0.05–0.2	180	Y	N
2	Control	73.9	373	50	0	240	0.05–0.1	230	Y	N
3	Control	83.5	536	140	250	747	0.05–0.1	290	Y	N
4	Control	86.9	429	130	0	240	0.02–0.1	250	Y	N
5	Control	77.9	157	50	500	0	0	0	N	N
6	Control	88.4	519	70	0	352	0.04–0.15	400	Y	N
7	Control	85.3	750	100	0	0	0.02–0.5	240	Y	N
8	Control	72	396	130	125	280	0.05–0.15	200	Y	N
9	Control	67	329	100	0	433	0.02–0.1	490	Y	N
10	Control	87.2	193	80	250	0	0.1–0.15	0	Y	N
11	Control	68.5	408	100	0	0	0.02–0.1	180	Y	N
12	Control	54.4	223	50	0	100	0.04–0.1	460	Y	N
13	EDAS	82	403	140	0	0	0.02–0.1	500	Y	N
14	EDAS	65	543	110	25	0	0.03–0.1	310	Y	N
15	EDAS	95.7	454	100	250	240	0.01–0.25	180	Y	N
16	EDAS	75.4	484	110	225	0	0	250	Y	N
17	EDAS	63.9	522	100	250	0	0	750	Y	Y
18	EDAS	81	446	130	250	0	0	200	Y	N
19	EDAS	63	428	190	0	80	0.01–0.08	250	Y	N
20	EDAS	64.3	389	100	0	0	0.03–0.1	230	Y	N
21	EDAS	60	447	80	150	0	0.02–0.4	140	Y	N
22	EDAS	52.8	454	80	250	105	0.03–0.1	100	Y	Y
23	EDAS	46.7	442	90	0	160	0.02–0.1	370	Y	N
24	EDAS	52	374	80	0	80	0.05–0.1	410	Y	N

Panel (B)
				Intraoperative blood pressure management
Subject ID	Group	Weight (kg)	Surgery Duration (min)	Phenylephrine* (µg)	Phenylephrine Drip (µg/kg/min)	Norepinephrine Drip (µg/kg/min)	Epinephrine* (µg)	Epinephrine Drip (µg/kg/min)	Nitroglycerine* (µg)	Ephedrine* (mg)	Esmolol* (mg)	Labetalol* (mg)
1	Control	68	321	100	0.01–0.4	0	0	0	0	15	0	75
2	Control	73.9	373	250	0	0	0	0	0	20	0	0
3	Control	83.5	536	200	0.05–0.35	0	0	0	0	0	30	10
4	Control	86.9	429	120	0.02–0.15	0	0	0	200	0	0	10
5	Control	77.9	157	0	0	0.1–0.15	0	0	0	0	0	0
6	Control	88.4	519	0	0	0	0	0	0	0	0	20
7	Control	85.3	750	600	0.2–0.5	0	0	0	0	0	0	0
8	Control	72	396	0	0	0	0	0	0	0	0	0
9	Control	67	329	420	0	0	0	0	500	0	0	35
10	Control	87.2	193	0	0	0.02–0.04	0	0	0	0	0	0
11	Control	68.5	408	500	0.2–1	0	0	0	250	0	0	0
12	Control	54.4	223	100	0	0	0	0	0	0	0	0
13	EDAS	82	403	2300	0.2–1	0.05–0.15	5	0	0	25	0	0
14	EDAS	65	543	1975	0.2–1	0	0	0	0	20	0	0
15	EDAS	95.7	454	2730	0.2–1	0	0	0	250	0	100	0
16	EDAS	75.4	484	1950	0.2–0.4	0	0	0	300	20	0	0
17	EDAS	63.9	522	2370	0.05–1	0	0	0	50	0	0	0
18	EDAS	81	446	1200	0	0	0	0	0	85	0	0
19	EDAS	63	428	1900	0.1–0.28	0	45	0	0	45	0	0
20	EDAS	64.3	389	600	0.2–0.5	0	0	0.01–0.13	0	0	0	0
21	EDAS	60	447	550	0.3–1.4	0	0	0	500	55	0	0
22	EDAS	52.8	454	200	0.2–1.2	0	0	0	0	0	0	0
23	EDAS	46.7	442	600	0.3–1	0	0	0	0	5	0	0
24	EDAS	52	374	1125	0.2–1.2	0	0	0	200	5	20	0

Panel (C)
				Intraoperative fluid and ventilatory management
Subject ID	Group	Weight (kg)	Surgery Duration (min)	Mannitol (g)	Mean Tidal Volume (mL)	Mean Respiratory Rate (breaths/min)	Normal Saline (mL)	Plasmalyte (mL)	Albumin 5% (mL)
1	Control	68	321	70	355.1	13.6	1000	1800	0
2	Control	73.9	373	37	529.4	11.3	1000	1000	0
3	Control	83.5	536	80	502.9	12.7	1000	2700	0
4	Control	86.9	429	63	534.3	11.1	1000	2500	0
5	Control	77.9	157	0	498.5	11.3	500	500	0
6	Control	88.4	519	20	415	13.1	0	3000	0
7	Control	85.3	750	67	500.7	11	0	5100	0
8	Control	72	396	70	449	13.9	1000	2600	0
9	Control	67	329	67	478.3	11.1	1000	3700	0
10	Control	87.2	193	100	471.1	17.8	51	1400	0
11	Control	68.5	408	68	464.1	12.5	1000	2500	0
12	Control	54.4	223	100	404.2	11.6	4000	1000	0
13	EDAS	82	403	0	530.6	12.1	0	5100	0
14	EDAS	65	543	0	481.3	8.9	1274	3800	250
15	EDAS	95.7	454	0	444.8	9.23	600	1800	0
16	EDAS	75.4	484	0	421.3	11.3	1500	2300	0
17	EDAS	63.9	522	0	455.2	8.84	1000	2900	0
18	EDAS	81	446	0	588.6	12.6	1000	3400	500
19	EDAS	63	428	0	446.7	13.2	500	2300	350
20	EDAS	64.3	389	0	490.6	14.2	1000	3300	0
21	EDAS	60	447	0	426.8	11.9	0	3000	0
22	EDAS	52.8	454	0	313.8	13.8	1000	3000	0
23	EDAS	46.7	442	0	343.6	11.3	1000	6500	0
24	EDAS	52	374	0	486.54	8	1500	2750	250