Risk factors for an MI as outcome of ACS (adjusted for differences in age and sex)
| Risk factors | OR | 95% CI | p Value |
|---|---|---|---|
| Male sex | 1.59 | 1.19 to 2.13 | 0.002 |
| Age (years) | 1.01 | 1.00 to 1.02 | 0.178 |
| hsCRP >2 mg/L | 1.75 | 1.30 to 2.34 | p for trend 0.037 |
| Sex (male vs female) | 1.73 | 1.26 to 2.34 | <0.001 |
| Age (years) | 1.00 | 0.98 to 1.02 | 0.872 |
| Serum amyloid | |||
| Tert 1 | 1.0 | p for trend 0.216 | |
| Tert 2 | 1.39 | 0.98 to 1.97 | 0.063 |
| Tert 3 | 1.66 | 1.16 to 2.36 | 0.006 |
| Fibrino | |||
| Tert 1 | 1.00 | p for trend 0.010 | |
| Tert 2 | 1.26 | 0.90 to 1.94 | 0.174 |
| Tert 3 | 1.62 | 1.12 to 2.35 | 0.011 |
| Leuco | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 2.78 | 1.97 to 3.92 | <0.001 |
| Tert 3 | 9.64 | 6.42 to 14.5 | <0.001 |
| Neutro | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 2.96 | 2.09 to 4.20 | <0.001 |
| Tert 3 | 8.91 | 5.97 to 13.3 | <0.001 |
| Eosino | |||
| Tert 1 | 1.00 | p for trend 0.002 | |
| Tert 2 | 0.65 | 0.45 to 0.94 | 0.021 |
| Tert 3 | 0.56 | 0.39 to 0.80 | 0.001 |
| Mono | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 1.29 | 0.92 to 1.82 | 0.140 |
| Tert 3 | 3.18 | 2.20 to 4.61 | <0.001 |
| T-cyt | |||
| Tert 1 | 1.00 | p for trend 0.016 | |
| Tert 2 | 1.14 | 0.81 to 1.61 | 0.445 |
| Tert 3 | 1.48 | 1.05 to 2.09 | 0.025 |
| T-mcv | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 0.46 | 0.32 to 0.65 | <0.001 |
| Tert 3 | 0.51 | 0.35 to 0.72 | <0.001 |
Associations between risk factors and an adverse outcome of ACS were estimated using binary logistic regression and expressed as ORs with 95% CIs adjusting for differences in age and sex. Plasma levels of hsCRP were dichotomised at 2 mg/L, while other biomarkers were divided in tertiles for categorical comparisons using tertile 1 as reference. The continuous format of the variables was used to test for trend, however, due to skewed distributions, the tertiles were used as a linear variable for trend test of concentration of fibrinogen, eosinophil cell count and T-mcv.
ACS, acute coronary syndrome; eosino, eosinophil cell count; fibrino, fibrinogen; hsCRP, high-sensitivity C reactive protein; leuco, leucocyte cell count; MI, myocardial infarction; mono, monocyte cell count; neutro, neutrophil cell count; T-cyt, thrombocyte cell count; T-mcv, thrombocyte median cell volume; tert, tertile.