Risk factors for an MI as outcome of ACS
| Risk factors | OR | 95% CI | p Value |
|---|---|---|---|
| Covariates in model: sex, age, smoking, duration of symptoms | |||
| p for trend 0.225 | |||
| hsCRP >2 mg/L | 1.40 | 1.00 to 1.96 | 0.049 |
| Male sex | 1.50 | 1.04 to 2.17 | 0.031 |
| Age (years) | 1.01 | 0.99 to 1.03 | 0.566 |
| Smoking (yes/no) | 2.15 | 1.39 to 3.32 | 0.001 |
| Duration (≥4 vs <4 h) | 1.41 | 0.98 to 2.03 | 0.061 |
| Serum amyloid | |||
| Tert 1 | 1.0 | p for trend 0.679 | |
| Tert 2 | 1.43 | 0.96 to 2.13 | 0.078 |
| Tert 3 | 1.28 | 0.84 to 1.93 | 0.248 |
| Fibrino | |||
| Tert 1 | 1.00 | p for trend 0.031 | |
| Tert 2 | 1.19 | 0.82 to 1.74 | 0.349 |
| Tert 3 | 1.62 | 1.03 to 2.55 | 0.039 |
| Leuco | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 2.58 | 1.74 to 3.83 | <0.001 |
| Tert 3 | 7.39 | 4.69 to 11.6 | <0.001 |
| Neutro | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 2.58 | 1.74 to 3.83 | <0.001 |
| Tert 3 | 7.39 | 4.69 to 11.6 | <0.001 |
| Eosino | |||
| Tert 1 | 1.00 | p for trend 0.003 | |
| Tert 2 | 0.69 | 0.45 to 1.07 | 0.069 |
| Tert 3 | 0.54 | 0.35 to 0.81 | 0.003 |
| Mono | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 0.99 | 0.67 to 1.47 | 0.978 |
| Tert 3 | 2.36 | 1.54 to 3.62 | <0.001 |
| T-cyt | |||
| Tert 1 | 1.00 | p for trend 0.052 | |
| Tert 2 | 1.12 | 0.75 to 1.66 | 0.584 |
| Tert 3 | 1.61 | 1.08 to 2.39 | 0.020 |
| T-mcv | |||
| Tert 1 | 1.00 | p for trend <0.001 | |
| Tert 2 | 0.41 | 0.27 to 0.61 | <0.001 |
| Tert 3 | 0.45 | 0.30 to 0.68 | <0.001 |
Multivariate analysis adjusted for differences in age, sex, smoking and duration of symptoms.
Associations between risk factors and an adverse outcome of ACS were estimated using binary logistic regression and expressed as ORs with 95% CIs. All models included sex, age, smoking and duration of chest pain as covariates beside the specified risk factor itself. Plasma levels of hsCRP ≥2 mg/L were compared to those below, while other biomarkers were divided in tertiles for categorical comparisons using tertile 1 as reference. The continuous format of the variables was used to test for trend, however, due to skewed distributions, the tertiles were used as a linear variable for trend test of concentration of fibrinogen, eosinophil cell count and T-mcv.
ACS, acute coronary syndrome; eosino, eosinophil cell count; fibrino, fibrinogen; hsCRP, high-sensitivity C reactive protein; leuco, leucocyte cell count; MI, myocardial infarction; mono, monocyte cell count; neutro, neutrophil cell count; T-cyt, thrombocyte cell count; T-mcv, thrombocyte median cell volume; tert, tertile.