Table 2

Interaction (G×E) and correlation (rGE) between genetic variants of genes of monoamine neurotransmission and measures of early development (G×E_Dev, rGE_Dev)* and of social environment (G×E_Soc, rG_Soc)† and gender (G×Sex) on current depressive symptoms (Hopkins Symptom Check List score), and genetic association with Hopkins Symptom Check List score in the complete study sample from the NFBC 1966 (All)

Gene	Gene name	Chromosome	SNP	Position/bp	Minor allele	MAF^‡	P (G×E_Dev)	P (G×E_Soc)	P (G×sex)	P (All)	P (rGE_Dev)	P (rG_Soc)
SLC6A4	Serotonin transporter	17	rs1906451	25539605	G	0.44	0.608	0.363	0.784	0.268	0.747	0.035
			rs3794808	25555919	A	0.41	0.365	0.263	0.799	0.320	0.402	0.064
			rs140700	25567515	A	0.09	0.133	0.460	0.037^§§	0.876	0.209	0.614
			rs2066713	25575791	A	0.46	0.253	0.499	0.505	0.550	0.778	0.092
			rs8071667	25576899	A	0.15	0.473	0.682	0.122	0.606	0.961	0.827

TPH2	Tryptophan hydroxylase 2	12	rs4131348	70610746	G	0.12	0.844	0.937	0.400	0.497	0.705	0.241
			rs2129575	70626340	A	0.22	0.787	0.682	0.432	0.423	0.173	0.298
			rs1386496	70637057	G	0.16	0.983	0.404	0.293	0.792	0.837	0.226
			rs2171363	70646531	A	0.43	0.762	0.983	0.016^§§	0.814	0.692	0.940
			rs10506645	70671767	A	0.23	0.996	0.756	0.102	0.789	0.888	0.721
			rs1386497	70678557	C	0.17	0.816	0.131	0.452	0.797	0.640	0.172
			rs1487276	70691326	A	0.21	0.888	0.088	0.838	0.908	0.591	0.219
			rs9325202	70693744	A	0.48	0.805	0.074	0.488	0.473	0.913	0.675
			rs1487275	70696559	C	0.37	0.972	0.054	0.625	0.049^***	0.861	0.638
			rs1386483	70698761	A	0.47	0.574	0.090	0.326	0.437	0.294	0.625
			rs1872824	70716581	A	0.35	0.652	0.121	0.211	0.494	0.772	0.331

COMT	Catechol-O-methyltransferase	22	rs6518591	18304021	G	0.16	0.688	0.255	0.919	0.303	0.150	0.385
			rs737866	18310109	G	0.18	0.028^§	0.853	0.024^§§	0.755	0.623	0.489
			rs1544325	18311668	G	0.48	0.318	0.376	0.192	0.822	0.999	0.931
			rs174675	18314051	A	0.29	0.465	0.278	0.580	0.958	0.724	0.532
			rs5993883	18317638	C	0.36	0.230	0.495	0.025^§§	0.920	0.363	0.219
			rs2239393	18330428	G	0.31	0.005^¶	0.765	0.256	0.930	0.838	0.459
			rs4680	18331271	G	0.45	0.020^**	0.956	0.501	0.346	0.412	0.498
			rs4646316	18332132	A	0.18	0.205	0.165	0.933	0.026^†††	0.521	0.392
			rs165774	18332561	A	0.25	0.081	0.516	0.089	0.215	0.538	0.239
			rs165815	18339473	G	0.20	0.537	0.309	0.431	0.281	0.338	0.158
			rs887199	18341955	A	0.20	0.544	0.325	0.401	0.306	0.314	0.168
			rs2239395	18342203	C	0.02	0.144	0.655	0.153	0.390	0.224	0.664

MAOA	Monoamine oxidase A	X	rs909525	43438146	G	0.45	0.559	0.871	0.554	0.165	0.255	0.932
			rs12843268	43458610	A	0.40	0.271	0.837	0.266	0.103	0.052	0.932
			rs6610845	43472954	G	0.41	0.232	0.795	0.263	0.170	0.060	0.524
			rs3027409	43491977	C	0.02	0.748	0.928	0.950	0.194	0.703	0.068
			rs6609257	43497652	G	0.50	0.848	0.320	0.470	0.077	0.075	0.898
			rs3027415	43499385	G	0.18	0.218	0.550	0.905	0.613	0.105	0.408

DRD1	Dopamine receptor D1	5	rs265973	174793305	G	0.50	0.529	0.614	0.549	0.888	0.047	0.831
			rs265974	174793846	G	0.35	0.391	0.612	0.912	0.659	0.066	0.859
			rs265976	174795026	A	0.23	0.578	0.707	0.915	0.826	0.077	0.933
			rs5326	174802802	A	0.19	0.615	0.886	0.852	0.588	0.273	0.197

DRD2	Dopamine receptor D2	11	rs1800497	112776038	A	0.17	0.079	0.825	0.691	0.467	0.921	0.264
			rs2242592	112784640	G	0.37	0.757	0.466	0.283	0.736	0.143	0.393
			rs1076563	112801119	C	0.50	0.053	0.813	0.897	0.662	0.234	0.856
			rs2471857	112803549	A	0.17	0.518	0.494	0.823	0.901	0.884	0.126
			rs4620755	112814829	A	0.22	0.383	0.997	0.951	0.176	0.065	0.992
			rs7125415	112815891	A	0.19	0.084	0.389	0.789	0.231	0.163	0.947
			rs4648318	112818599	G	0.34	0.711	0.885	0.631	0.684	0.214	0.466
			rs4274224	112824662	G	0.24	0.067	0.777	0.017^¶¶	0.022^‡‡‡	0.536	0.766
			rs4581480	112829684	G	0.07	0.184	0.521	0.210	0.009^§§§	0.082	0.760
			rs7131056	112834984	C	0.49	0.564	0.795	0.413	0.964	0.622	0.138
			rs4938019	112846601	G	0.23	0.069	0.651	0.643	0.584	0.320	0.059
			rs12364283	112852165	G	0.08	0.280	0.504	0.441	0.861	0.633	0.804
			rs10891556	112857971	A	0.24	0.076	0.519	0.638	0.589	0.380	0.052
			rs6589377	112860946	G	0.17	0.286	0.617	0.061	0.552	0.502	0.915

DRD3	Dopamine receptor D3	3	rs2087017	115324703	G	0.43	0.937	0.921	0.606	0.743	0.835	0.828
			rs2134655	115340891	A	0.28	0.454	0.554	0.129	0.507	0.209	0.330
			rs963468	115345577	A	0.38	0.809	0.777	0.902	0.608	0.609	0.580
			rs3773678	115352768	A	0.06	0.780	0.855	0.487	0.770	0.972	0.556
			rs2630351	115357749	A	0.03	0.954	0.144	0.168	0.999	0.811	0.211
			rs167771	115358965	G	0.18	0.862	0.638	0.406	0.514	0.416	0.966
			rs167770	115362252	G	0.31	0.260	0.911	0.298	0.694	0.593	0.982
			rs226082	115363703	G	0.31	0.261	0.911	0.301	0.690	0.594	0.983
			rs324029	115364313	A	0.31	0.259	0.913	0.296	0.722	0.593	0.964
			rs10934256	115368342	A	0.17	0.229	0.898	0.478	0.246	0.147	0.669
			rs1486009	115371222	G	0.12	0.721	0.667	0.745	0.571	0.387	0.600
			rs6280	115373505	G	0.33	0.159	0.485	0.141	0.667	0.386	0.880
			rs9825563	115382910	G	0.23	0.045^††	0.902	0.211	0.215	0.028	0.927

DRD4	Dopamine receptor D4	11	rs3758653	626399	G	0.23	0.300	0.752	0.249	0.980	0.322	0.905
			rs11246226	631191	A	0.49	0.749	0.748	0.166	0.925	0.908	0.097

DRD5	Dopamine receptor D5	4	rs1878943	9375986	A	0.21	0.586	0.686	0.482	0.386	0.988	0.605
			rs13106539	9406801	G	0.39	0.735	0.062	0.067	0.044^¶¶¶	0.532	0.384

The analyses were performed using PLINK's linear and logistic regression models and interaction analysis. Empirical p values based on max(T) permutation are reported, with p values <0.05 shown in bold.
* Defined by the presence of two out of three possible indicators for high early developmental risk: low birth weight, late motor development and late development of speech.
† Defined by the presence of two out of five possible indicators for high social risk environment: unwanted pregnancy, low socio-economic status, single parenthood, low level of education of mother and low activity for information retrieval by the mother.
‡ Minor allele frequency.
§ p=0.0364 (β=0.0414).
¶ p=0.008 (β=0.0440).
** p=0.042 (β=0.0320).
†† p=0.022 (β=–0.0396) in individuals at high risk group.
§§ p>0.05 in both genders.
¶¶ p=0.0006 (β=0.023) in males.
*** β=0.008.
††† β=0.012.
‡‡‡ β=0.011.
§§§ β=0.022.
¶¶¶ β=−0.