Table 4

Top 20 pathways associated with the 135 in silico replicated differentially expressed genes after excluding the Finnish experiment

PathwayNo of differentially expressed genes in the pathway/total no of genes in the pathwayFisher exact test p value
Glucocorticoid receptor signalling22/2503.7E–14
IL-17 signalling9/707.0E–08
Pancreatic adenocarcinoma signalling10/1021.8E–07
IL-6 signalling9/885.2E–07
IL-2 signalling7/521.5E–06
Phosphatase and Tensin Homolog (PTEN) signalling9/1011.7E–06
IL-15 signalling7/604.1E–06
Agrin interactions at neuromuscular junction7/604.1E–06
Tumor Necrosis Factor Receptor 1 (TNFR1) signalling6/459.4E–06
p21-Activated Protein Kinase (PAK) signalling7/751.9E–05
Phosphoinositide 3-Kinase (PI3K)/AKT signalling8/1082.5E–05
Regulation of IL-2 expression in activated and anergic T lymphocytes7/792.6E–05
Molecular mechanisms of cancer13/3033.0E–05
PPAR signalling7/813.1E–05
Aryl hydrocarbon receptor signalling8/1154.0E–05
Role of Janus Kinase 1 (JAK1) and Januse Kinase 3 (JAK3) in γc cytokine signalling6/594.6E–05
Nuclear factor (NF)-κβ signalling9/1545.2E–05
Stress-Activated Protein Kinase (SAPK)/c-Jun N-terminal Kinase (JNK) signalling7/906.1E–05
Renal cell carcinoma signalling6/647.3E–05
IL-4 signalling6/647.3E–05
  • IL, interleukin.