Percentage of children with symptom | CF versus Influvac | CF versus Influvac (controlling for age) | ||||||
Fluvax (n=109) | Fluvax Junior (n=100) | Combined Fluvax and Fluvax Junior (CF) (n=209) | Influvac (n=110) | Univariate χ2 p value | OR (95% CI) | p Value | ||
Reported symptom | Fever* | 52.3 | 61.0 | 56.5 | 17.3 | 0.00001 | 5.1 (2.9 to 9.2) | 0.0001 |
Fatigue | 29.4 | 37.0 | 33.0 | 10.9 | 0.0001 | 3.5 (1.8 to 7.0) | 0.0003 | |
Vomiting | 14.7 | 20.0 | 17.2 | 2.7 | 0.0001 | 6.0 (1.8 to 20.3) | 0.0037 | |
Rigours | 11.9 | 19.0 | 15.3 | 0.9 | 0.0006 | 16.0 (2.1 to 119.5) | 0.0070 | |
Swelling | 12.8 | 13.0 | 12.9 | 10.9 | 0.6 | 1.1 (0.5 to 2.3) | 0.7914 | |
Diarrhoea | 6.4 | 4.0 | 5.3 | 0.9 | 0.052 | 5.3 (0.7 to 43.0) | 0.1160 | |
Rash | 5.5 | 2.0 | 3.8 | 0.9 | 0.14 | 3.8 (0.5 to 31.2) | 0.2193 | |
Headache | 3.7 | 3.0 | 3.4 | 0.9 | 0.18 | 4.3 (0.5 to 37.5) | 0.1843 | |
Convulsions | 2.8 | 0.0 | 1.4 | 0.0 | 0.2 | NA | ||
Significant SFAE | 22.9 | 36.0 | 29.2 | 4.5 | 0.0001 | 7.0 (2.7 to 18.3) | 0.0001 |
Percentage of children answering ‘Yes’ (n) | CF versus Influvac | CF versus Influvac (controlling for age) | ||||||
Fluvax (n=109) | Fluvax Junior (n=100) | Combined Fluvax and Fluvax Junior (CF) (n=209) | Influvac (n=110) | Univariate χ2 p value | OR (95% CI) | p Value | ||
Prior influenza vaccination history | Had monovalent 2009 H1N1 pandemic influenza vaccine? (n=104) | 15.4 (104) | 15.6 (96) | 15.5 (200) | 19.6 (102) | 0.37 | 0.9 (0.4 to 1.6) | 0.64 |
Had seasonal influenza vaccine before 2010? (n=107) | 50.5 (107) | 49 (100) | 49.8 (207) | 57.5 (108) | 0.19 | 1.5 (0.9 to 2.6) | 0.16 |
SFAE, significant febrile adverse event (defined as fever ≥39°C and/or rigours and/or a febrile convulsion).
↵* Self-reported fever, whether measured or not.