Table 5

Overall and stratified meta-analyses of the association between COX-2 polymorphisms and risk of hepatocellular carcinoma

Comparison	Population	No. included in the study	Test of association*				Test of heterogeneity
Comparison	Population	No. included in the study	OR	95% CI	p Value	Model	p Value	I²
COX-2 A-1195G (rs689466)
G allele vs A allele	Overall	8	0.87	0.75 to 1.02	0.09	R	0.007	64
	Chinese	5	0.84	0.72 to 0.99	0.04	R	0.02	65
	Non-Chinese	3	1.00	0.63 to 1.59	0.99	R	0.02	74
GG vs GA+AA	Overall	8	0.72	0.57 to 0.92	0.008	R	0.04	52
	Chinese	5	0.79	0.62 to 1.01	0.06	R	0.06	55
	Non-Chinese	3	0.49	0.30 to 0.78	0.003	F	0.66	0
GG vs AA	Overall	8	0.72	0.53 to 0.97	0.03	R	0.02	57
	Chinese	5	0.71	0.51 to 0.99	0.05	R	0.02	66
	Non-Chinese	3	0.77	0.32 to 1.84	0.56	R	0.13	52
AA vs GA+GG	Overall	8	1.05	0.77 to 1.44	0.74	R	<0.001	79
	Chinese	5	1.23	0.98 to 1.55	0.07	R	0.06	57
	Non-Chinese	3	0.69	0.24 to 2.03	0.51	R	<0.001	90
COX-2 G-765C (rs20417)
C allele vs G allele	Overall	6	1.32	0.76 to 2.30	0.33	R	<0.001	88
CC vs GC+GG	Overall	3	0.88	0.16 to 4.75	0.88	R	0.007	80
CC vs GG	Overall	3	0.93	0.16 to 5.35	0.94	R	0.005	81
GG vs CC+GC	Overall	6	0.48	0.14 to 1.59	0.23	R	<0.001	97
COX-2 T+8473C (rs5275)
C allele vs T allele	Overall	3	0.99	0.86 to 1.14	0.91	F	0.67	0
CC vs CT+TT	Overall	3	1.31	0.83 to 2.07	0.25	F	0.37	0
CC vs TT	Overall	3	1.25	0.78 to 1.98	0.35	F	0.33	0
TT vs CT+CC	Overall	3	1.05	0.89 to 1.24	0.58	F	0.57	0

*Mantel–Haenszel estimate was used to give a pooled OR using the fixed-effect models, and a [Bold] indicates p value served as the threshold for statistical significance. DerSimonian–Laird estimate was used for random-effect models.
F, fixed-effect model; R, random-effect model.