Comparison | Population | No. included in the study | Test of association* | Test of heterogeneity | ||||
---|---|---|---|---|---|---|---|---|
OR | 95% CI | p Value | Model | p Value | I2 | |||
COX-2 A-1195G (rs689466) | ||||||||
G allele vs A allele | Overall | 8 | 0.87 | 0.75 to 1.02 | 0.09 | R | 0.007 | 64 |
Chinese | 5 | 0.84 | 0.72 to 0.99 | 0.04 | R | 0.02 | 65 | |
Non-Chinese | 3 | 1.00 | 0.63 to 1.59 | 0.99 | R | 0.02 | 74 | |
GG vs GA+AA | Overall | 8 | 0.72 | 0.57 to 0.92 | 0.008 | R | 0.04 | 52 |
Chinese | 5 | 0.79 | 0.62 to 1.01 | 0.06 | R | 0.06 | 55 | |
Non-Chinese | 3 | 0.49 | 0.30 to 0.78 | 0.003 | F | 0.66 | 0 | |
GG vs AA | Overall | 8 | 0.72 | 0.53 to 0.97 | 0.03 | R | 0.02 | 57 |
Chinese | 5 | 0.71 | 0.51 to 0.99 | 0.05 | R | 0.02 | 66 | |
Non-Chinese | 3 | 0.77 | 0.32 to 1.84 | 0.56 | R | 0.13 | 52 | |
AA vs GA+GG | Overall | 8 | 1.05 | 0.77 to 1.44 | 0.74 | R | <0.001 | 79 |
Chinese | 5 | 1.23 | 0.98 to 1.55 | 0.07 | R | 0.06 | 57 | |
Non-Chinese | 3 | 0.69 | 0.24 to 2.03 | 0.51 | R | <0.001 | 90 | |
COX-2 G-765C (rs20417) | ||||||||
C allele vs G allele | Overall | 6 | 1.32 | 0.76 to 2.30 | 0.33 | R | <0.001 | 88 |
CC vs GC+GG | Overall | 3 | 0.88 | 0.16 to 4.75 | 0.88 | R | 0.007 | 80 |
CC vs GG | Overall | 3 | 0.93 | 0.16 to 5.35 | 0.94 | R | 0.005 | 81 |
GG vs CC+GC | Overall | 6 | 0.48 | 0.14 to 1.59 | 0.23 | R | <0.001 | 97 |
COX-2 T+8473C (rs5275) | ||||||||
C allele vs T allele | Overall | 3 | 0.99 | 0.86 to 1.14 | 0.91 | F | 0.67 | 0 |
CC vs CT+TT | Overall | 3 | 1.31 | 0.83 to 2.07 | 0.25 | F | 0.37 | 0 |
CC vs TT | Overall | 3 | 1.25 | 0.78 to 1.98 | 0.35 | F | 0.33 | 0 |
TT vs CT+CC | Overall | 3 | 1.05 | 0.89 to 1.24 | 0.58 | F | 0.57 | 0 |
*Mantel–Haenszel estimate was used to give a pooled OR using the fixed-effect models, and a [Bold] indicates p value served as the threshold for statistical significance. DerSimonian–Laird estimate was used for random-effect models.
F, fixed-effect model; R, random-effect model.