Association of aminotransferase ratio with fatty liver diagnosis in various adjustment models (hierarchical multiple logistic regression)
| ALT/AST ratio (per SD increase) | ||||||
|---|---|---|---|---|---|---|
| NAFLD | High-degree NAFLD | |||||
| Model | OR | 95% of CI | p Value | OR | 95% of CI | p Value |
| Unadjusted model | 1.83 | 1.34 to 2.49 | <0.001 | 2.39 | 1.59 to 3.56 | <0.001 |
| Model 1 | 1.82 | 1.34 to 2.49 | <0.001 | 2.38 | 1.60 to 3.58 | <0.001 |
| Model 2 | 1.81 | 1.33 to 2.48 | <0.001 | 2.37 | 1.58 to 3.55 | <0.001 |
| Model 3 | 1.81 | 1.31 to 2.52 | <0.001 | 2.03 | 1.32 to 3.11 | 0.001 |
| Model 4 | 1.77 | 1.27 to 2.48 | 0.001 | 1.95 | 1.25 to 3.04 | 0.003 |
Model 1 adjusted for age and gender.
Model 2: further adjusted for body mass index and waist to hip ratio.
Model 3: further adjusted for serum creatinine, uric acid, log GGT.
Model 4: further adjusted for metabolic syndrome, low-density lipoprotein and cholesterol (residual lipid profiles).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase; NAFLD, non-alcoholic fatty liver disease.