Diagnostic accuracy of AA index in the estimation and validation cohorts
| Cut-off | S0–1 | S2–4 | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | +LR | -LR |
|---|---|---|---|---|---|---|---|---|
| Estimation cohort (N=253) | 207 | 46 | ||||||
| Low cut-off | 91.3 (51.8–99.7) | 50.0 (37.8–62.2) | 28.8 (6.0–62.2) | 96.3 (86.4–99.5) | 1.83 (1.3–2.5) | 0.17 (0.03–1.2) | ||
| <0.007 | 103 | 4 | ||||||
| ≥0.007 | 104 | 42 | ||||||
| High cut-off | 65.2 (29.9–92.5) | 90.0 (80.5–95.5) | 60.0 (9.4–90.6) | 92.1 (82.7–96.9) | 6.52 (2.3–15.7) | 0.39 (0.1–1.3) | ||
| <0.127 | 186 | 16 | ||||||
| ≥0.127 | 20 | 30 | ||||||
| Validation cohort (N=253) | 211 | 42 | ||||||
| Low cut-off | 90.5 (51.6–97.7) | 42.2 (31.2–54.0) | 23.8 (6.5–45.5) | 95.7 (78.1–99.9) | 1.57 (0.6–9.5) | 0.23 (0.04–1.8) | ||
| <0.007 | 89 | 4 | ||||||
| ≥0.007 | 122 | 38 | ||||||
| High cut-off | 66.7 (34.9–94.1) | 88.2 (79.2–94.3) | 52.8 (0.8–90.6) | 93.0 (79.6–97.6) | 5.65 (0.5–18.2) | 0.38 (0.05–2.0) | ||
| <0.127 | 186 | 14 | ||||||
| ≥0.127 | 25 | 28 |
+LR, positive likelihood ratio; −LR, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.