Diabetes | MI | Stroke | Fatal MI | Fatal stroke | ||||||
---|---|---|---|---|---|---|---|---|---|---|
N | HR (95% CI) | N | HR (95% CI) | N | HR (95% CI) | N | HR (95% CI) | N | HR (95% CI) | |
Overall BMI | 4842 | 1.21 (1.18 to 1.24)a | 4842 | 1.06 (1.04 to 1.08)a | 4842 | 1.04 (1.01 to 1.07)b | 4842 | 1.07 (1.04 to 1.10)a | 4842 | 1.02 (0.97 to 1.07) |
BMI-21 quintiles | ||||||||||
0–20% | 963 | 1.17 (1.11 to 1.23)a | 963 | 1.06 (1.02 to 1.11)b | 963 | 1.04 (0.98 to 1.11) | 963 | 1.06 (0.998 to 1.13) | 963 | 1.07 (0.95 to 1.21) |
21–40% | 971 | 1.30 (1.20 to 1.40)a | 971 | 1.08 (1.02 to 1.14)b | 971 | 1.03 (0.96 to 1.11) | 971 | 1.07 (0.99 to 1.15) | 971 | 0.93 (0.82 to 1.06) |
41–60% | 971 | 1.24 (1.16 to 1.32)a | 971 | 1.10 (1.04 to 1.16)a | 971 | 1.09 (1.02 to 1.17)b | 971 | 1.12 (1.05 to 1.21)b | 971 | 1.04 (0.91 to 1.18) |
61–80% | 965 | 1.29 (1.21 to 1.38)a | 965 | 1.11 (1.05 to 1.17)a | 965 | 1.05 (0.97 to 1.14) | 965 | 1.07 (0.99 to 1.15) | 965 | 1.07 (0.93 to 1.23) |
81–100% | 972 | 1.27 (1.21 to 1.34)a | 972 | 1.06 (1.01 to 1.11)b | 972 | 1.06 (0.998 to 1.14) | 972 | 1.09 (1.03 to 1.16)b | 972 | 1.09 (0.97 to 1.23) |
p trend | 0.19 | 0.82 | 0.62 | 0.63 | 0.47 |
HR for the effect of a 1 kg/m2 increase in BMI in middle adulthood, adjusted for age, smoking status in middle life and town (fixed effect).
ap<0.001, bp<0.05.
BMI, body mass index; MI, myocardial infarction; N, number of participants; p trend, p value for trend across groups regarding the effect of BMI-50 (obtained from metaregression).