Table 5

HRs for the associations between BMI at mean age 50 years and all outcomes, stratified by BMI at mean age 21 years

	Diabetes		MI		Stroke		Fatal MI		Fatal stroke
	N	HR (95% CI)	N	HR (95% CI)	N	HR (95% CI)	N	HR (95% CI)	N	HR (95% CI)
Overall BMI	4842	1.21 (1.18 to 1.24)^a	4842	1.06 (1.04 to 1.08)^a	4842	1.04 (1.01 to 1.07)^b	4842	1.07 (1.04 to 1.10)^a	4842	1.02 (0.97 to 1.07)
BMI-21 quintiles
0–20%	963	1.17 (1.11 to 1.23)^a	963	1.06 (1.02 to 1.11)^b	963	1.04 (0.98 to 1.11)	963	1.06 (0.998 to 1.13)	963	1.07 (0.95 to 1.21)
21–40%	971	1.30 (1.20 to 1.40)^a	971	1.08 (1.02 to 1.14)^b	971	1.03 (0.96 to 1.11)	971	1.07 (0.99 to 1.15)	971	0.93 (0.82 to 1.06)
41–60%	971	1.24 (1.16 to 1.32)^a	971	1.10 (1.04 to 1.16)^a	971	1.09 (1.02 to 1.17)^b	971	1.12 (1.05 to 1.21)^b	971	1.04 (0.91 to 1.18)
61–80%	965	1.29 (1.21 to 1.38)^a	965	1.11 (1.05 to 1.17)^a	965	1.05 (0.97 to 1.14)	965	1.07 (0.99 to 1.15)	965	1.07 (0.93 to 1.23)
81–100%	972	1.27 (1.21 to 1.34)^a	972	1.06 (1.01 to 1.11)^b	972	1.06 (0.998 to 1.14)	972	1.09 (1.03 to 1.16)^b	972	1.09 (0.97 to 1.23)
p trend		0.19		0.82		0.62		0.63		0.47

HR for the effect of a 1 kg/m² increase in BMI in middle adulthood, adjusted for age, smoking status in middle life and town (fixed effect).
^ap<0.001, ^bp<0.05.
BMI, body mass index; MI, myocardial infarction; N, number of participants; p trend, p value for trend across groups regarding the effect of BMI-50 (obtained from metaregression).