Relative risk for low Apgar score (≤7) in AED exposed and unexposed children stratified on mother's diagnosis of epilepsy (monotherapy and polytherapy combined)
| Epilepsy | AED | N (%) | Apgar score ≤7, n (%) | Apgar score >7, n (%) | Relative risk, crude (95% CI) | Relative risk, adjusted* (95% CI) |
|---|---|---|---|---|---|---|
| Yes | Yes | 2215 (100) | 39 (1.8) | 2176 (98.2) | 1.38 (0.94 to 2.04) | 1.34 (0.90 to 2.01) |
| No | 5261 (100) | 67 (1.3) | 5194 (98.7) | 1.00 (reference) | 1.00 (reference) | |
| No | Yes | 691 (100) | 16 (2.3) | 675 (97.7) | 1.77 (1.09 to 2.88) | NA (–) |
| No | 668 854 (100) | 8730 (1.3) | 660 124 (98.7) | 1.00 (reference) | NA (–) |
*Apgar score was adjusted for smoking.
AED, antiepileptic drug; NA, not applicable.