Table 4

Predicted typical change in domain specific HRQoL (%) from an initial HRQoL in the range 20–80%

Domain	Age 5 years increase	BMI 1 unit decrease	FEV₁% 10% decrease	CFRD	TIVAD
Physical functioning	1.5–2.5	1.5–2.4	3.0–4.9	1.1–1.7	4.9–8.4
Social functioning	1.7–2.8	1.2–1.8	2.0–3.3	2.2–6.9	1.7–2.8
Emotional responses	2.8–4.6	0.7–1.1	1.7–2.7	2.5–4.1	2.0–3.2
Treatment issues	2.8–4.6	1.4–2.2	0.9–1.9	1.8–2.9	5.2–9.0
Chest symptoms	1.0–1.6	1.5–2.4	2.6–4.2	3.2–5.3	5.0–8.5
Body image	0.1–0.2	2.3–3.8	0.1–0.2	3.3–5.6	4.3–7.3
Interpersonal relationships	1.3–2.0	0.1–0.1	1.6–2.6	1.7–2.8	2.4–3.9
Career concerns	2.2–3.6	0.6–0.9	2.4–3.9	0.8–1.2	6.4–11.5
Concerns for the future	2.8–4.6	0.9–1.4	0.6–0.9	1.2–1.8*	3.3–5.5

	Oral supplements	Enteral tube feeds	Burkholderia cepacia complex	Listed for transplant	Received transplant

Physical functioning	0.9–1.4	1.8–2.7*	5.1–8.8	5.3–9.2	4.2–7.1
Social functioning	1.5–2.3	2.2–3.5	8.5–16.1†	6.2–11.1	9.2–18.0
Emotional responses	1.4–2.2	0.6–1.0	3.6–6.0	5.0–8.6	5.2–7.4*
Treatment issues	2.8–4.7	2.3–3.7	5.6–9.7	5.0–8.7	12.9–16.6*
Chest symptoms	1.7–2.7	1.3–2.0*	6.6–11.8	5.7–10.0	15.4–19.4*
Body image	1.1–1.7	3.6–6.0	7.6–14.0	0.7–1.1	5.5–9.7
Interpersonal relationships	1.8–2.8*	2.4–3.5*	0.2–0.3	1.7–2.7	0.2–0.3
Career concerns	0.6–0.9	1.8–3.0	0.7–1.0*	4.6–7.9	9.0–17.5
Concerns for the future	0.0–0.1*	2.0–3.2	1.9–3.2	5.3–9.2	7.3–10.1*

The change is a decrease unless otherwise indicated by *.
†Interpretation of table values: With colonisation with B. cepacia complex, Social functioning% is expected to decline by between 8.5 and 16.1 points depending on the Social functioning% domain score before colonisation.
BMI, body mass index; CFRD, cystic fibrosis-related diabetes; FEV_1, forced expiratory volume in 1 s, TIVAD, totally implantable vascular access device.