Recommended interventions by the guidelines for migraine prophylaxis*
| Interventions | Minimum effective dose or treatment period, mg/day |
|---|---|
| Pharmacological interventions | |
| Antiepileptics | |
| Gabapentin | 900 |
| Topiramate | 100 |
| Antidepressants | |
| Amitriptyline | 10 |
| Nortriptyline | 10 |
| Antihypertensives and other calcium channel blockers | |
| Propranolol | 80 |
| Metoprolol | 100 |
| Nadolol | 80 |
| Flunarizine | 10 |
| Candesartan | 16 |
| Vitamins/minerals/herbals | |
| Riboflavin | 400 |
| Coenzyme Q10 | 300 |
| Magnesium | 600 |
| Butterbur (Petasites hybridus root extract) | 150 |
| Serotonin Antagonists | |
| Pizotifen (pizotyline) | |
| Non-pharmacological interventions | |
| Acupuncture | – |
| Relaxation training | – |
| Biofeedback | – |
| Cognitive–behavioural therapy | – |
*The recommended dose or treatment period was defined according to the guidelines developed by the American academy of neurology, the National Institute for Health and Care Excellence, the Scottish Intercollegiate Guidelines Network and the Canadian Headache Society. There is no standard reference for defining the minimum effective treatment period of the non-pharmacological interventions.