Parameters used for the economic evaluation of UPF for rotavirus vaccination and diarrhoeal treatment in Ethiopia
| Parameter | Value | Sources |
|---|---|---|
| Epidemiology | ||
| Under-5 deaths due to diarrhoea in 2011 | 23 700 | Walker et al11 |
| Proportion of under-5 diarrhoeal deaths attributed to rotavirus | 27% | Walker et al11 |
| Percentage of mortality, from poorest to richest (wealth quintile 1–5) | 31, 26, 18, 18, 6 | Authors’ calculations based on EDHS18 Rheingans et al;20 see online supplemental material |
| Interventions | ||
| Diarrhoeal treatment effectiveness | 0.93 | Munos et al12 |
| Rotavirus vaccine effectiveness (per 2-dose course) | 0.49 | Madhi et al*13 |
| Coverage of diarrhoeal treatment, from poorest to richest (wealth quintile 1–5), before UPF Coverage of diarrhoeal treatment, from poorest to richest (wealth quintile 1–5), after UPF | 22%; 25%; 35%; 33%; 53% 42%; 45%; 55%; 53%; 73% | EDHS18 |
| Coverage of vaccine (DTP2 rates), from poorest to richest (wealth quintile 1–5), before UPF Coverage of vaccine (DTP2 rates), from poorest to richest (wealth quintile 1–5), after UPF | 0%; 0%; 0%; 0%; 0% 42%; 45%; 47%; 57%; 78% | EDHS18 |
| Costs (2011) | ||
| Hospitalisation costs for diarrhoea | US$49 | Stack et al;24 WHO-CHOICE25 |
| Outpatient clinic visit costs for diarrhoea | US$9 | Stack et al;24 WHO-CHOICE25 |
| Transportation costs for inpatient visit | US$8 | Authors’ calculations based on;14 26 see online supplementary material |
| Transportation costs for outpatient visit | US$4 | Authors’ calculations based on;14 26 see online supplementary material |
| Probability of hospitalisation for diarrhoea, from poorest to richest (wealth quintile 1–5) | 0.02; 0.02; 0.01; 0.02; 0.01 | Authors’ calculations based on EDHS18 and Lamberti et al;27 see online supplementary material |
| Probability of outpatient visit for diarrhoea, from poorest to richest (wealth quintile 1–5) | 0.22; 0.25; 0.35; 0.33; 0.53 | EDHS18 |
| Vaccine price (per vial, 2 doses needed) | GAVI28 | |
| Base case | US$1.0 | |
| No GAVI subsidy | US$2.5 | |
| With GAVI subsidy | US$0.2 | |
| Vaccination system cost (per vial, 2 doses needed) | US$0.5 | Griffiths et al 29 |
| Ethiopia's gross domestic product per capita | US$360 | World Bank14 |
*Based on data from Malawi.
DPT, diphtheria, pertussis, tetanus; UPF, universal public finance.