Table 2

Mean serum levels of BNP in patients with KD and control patients

Author, country, yearBiomarkers testedDiagnostic kitControlsMean NP levels in patients with KD (SD)Mean NP levels in controls (SD)
Kawamura T, Japan, 2000BNPEnzyme immunoassay (SRL Co, Tokyo, Japan)Children with febrile viral illness, including adenovirus, influenza, measles and herpes group virus infections55.0±39.5 pg/mL6.8±7.3 pg/mL
Lee H, Korea, 2006NT-proBNPElecsys (Roche Diagnostics, Mannheim, Germany)Febrile children with skin rashes such as scarlet fever, exanthem subitum, urticaria and erythema multiform1510.6±2173.2 pg/mL139.0±88 pg/mL
Zhang QY, China, 2006NT-proBNPElecsys (Roche Diagnostics, Mannheim, Germany)Febrile children without KD or other chronic heart diseases691±86 pg/mL47±10 pg/mL
Dahdah N, Canada, 2009NT-proBNPElecsys (Roche Diagnostics, Indianapolis, IN)Children with a febrile illness unrelated to KD from 3 to 20 days923±1362.7 pg/mL186±198.0 pg/mL
Dahdah N, Canada, 2009BNPAxSYM (Abbott; Abbott Park, IL)Children with a febrile illness unrelated to KD from 3 to 20 days141.9±227.5 pg/mL59.9±72.4 pg/mL
Sun YP, China, 2010BNPAxSYM (Abbott; Abbott Park, IL)Febrile children without KD or other chronic heart diseases51.7±21.3 pg/mL3.76±7.6 pg/mL
Cho SY, Korea, 2011NT-proBNPElecsys (Roche Diagnostics, Mannheim, Germany)Age matched children with febrile illnesses, mostly respiratory tract infections749.66±997.11 pg/mL174.41±144.30 pg/mL
McNeal-Davidson A, Canada, 2012NT-proBNPElecsys (Roche Diagnostics, Indianapolis, IN)Children with fever unrelated to KD lasting between 4 and 14 days1287.7±2090.3 pg/mL199.5±274.3 pg/mL
Shiraishi M, Japan, 2013NT-proBNPElecsys (Roche Diagnostics, Tokyo, Japan)Children with other acute infectious diseaseNANA

  • BNP, B-type natriuretic peptide; KD, Kawasaki disease; NA, not applicable; NT-proBNP, N-terminal prohormone serum BNP.