Jadad Scale for the 11 randomised controlled studies
| Included studies | Randomisation | Allocation concealment | Blinding | Lost to follow-up | ITT analysis | Baseline | Quality grading |
|---|---|---|---|---|---|---|---|
| Alfonso et al14 | A | A | A | A | A | A | A |
| Butts et al15 | A | A | A | A | A | A | A |
| Butts et al16 | A | A | B | A | A | A | B |
| Butts et al17 | A | A | B | A | A | A | B |
| Manegold et al18 | A | A | B | A | A | A | B |
| Mitchell et al19 | A | A | A | A | A | A | A |
| Nemunaitis et al20 | A | B | B | A | A | A | B |
| Nemunaitis et al21 | A | B | B | A | A | A | B |
| O'Brien et al22 | A | A | B | A | A | A | B |
| Quoix et al23 | A | A | B | A | A | A | B |
| Vinageras et al24 | A | A | B | A | A | A | B |
Each criterion is graded as follows: A: adequate, with correct procedure; B: not described in sufficient detail to allow a definite judgement and C: inadequate procedures, methods or information. The grades of each criterion were added up and used to compare study quality in a quantitative manner. Each involved study has been graded in the last column (quality grading) as follows: A: studies have a low risk of bias, which were scored as grade A for all items; B: studies have a moderate risk of bias with one or more grades of B and C: studies have a high risk of bias with one or more grades of C.
ITT, intention to treat.