Adjusted HRs with 95% CIs for cancers occurring in women in the derivation cohort (breast, ovary, uterus)
| Cancer type | Adjusted HRs (95% CI) |
|---|---|
| Breast cancer* | |
| Ethnic group | |
| White/not recorded | 1.00 |
| Indian | 0.73 (0.64 to 0.83) |
| Pakistani | 0.71 (0.58 to 0.88) |
| Bangladeshi | 0.39 (0.27 to 0.56) |
| Other Asian | 0.78 (0.66 to 0.93) |
| Caribbean | 0.82 (0.73 to 0.93) |
| Black African | 0.75 (0.63 to 0.88) |
| Chinese | 0.73 (0.56 to 0.94) |
| Other | 0.83 (0.73 to 0.94) |
| Alcohol | |
| Non-drinker | 1.00 |
| Trivial drinker (<1 unit/day) | 1.05 (1.03 to 1.08) |
| Light drinker (1–2 units/day) | 1.11 (1.07 to 1.15) |
| Moderate drinker (3–6 units/day) | 1.21 (1.16 to 1.26) |
| Heavy drinker (7–9 units/day) | 1.31 (1.07 to 1.61) |
| Very heavy drinker (>9 units/day) | 1.25 (0.92 to 1.71) |
| Other baseline factors | |
| Family history of breast cancer | 1.93 (1.83 to 2.04)† |
| Benign breast disease | 1.51 (1.45 to 1.57) |
| Current oral contraceptive | 1.13 (1.07 to 1.20) |
| Current oestrogen containing HRT | 1.18 (1.15 to 1.22) |
| Manic depression or schizophrenia | 1.16 (1.04 to 1.30) |
| Prior lung cancer | 1.86 (1.21 to 2.85) |
| Prior blood cancer | 1.57 (1.31 to 1.88) |
| Prior ovarian cancer | 1.42 (1.12 to 1.80) |
| Ovarian cancer‡ | |
| Family history of ovarian cancer | 3.81 (2.72 to 5.33)† |
| Current oral contraceptive | 0.65 (0.54 to 0.79) |
| Prior breast cancer | 1.62 (1.41 to 1.88) |
| Prior cervical cancer | 1.60 (1.08 to 2.38) |
| Uterine cancer§ | |
| Smoking status | |
| Non-smoker | 1.00 |
| Ex-smoker | 0.82 (0.77 to 0.87) |
| Light smoker (1–9/day) | 0.83 (0.76 to 0.92) |
| Moderate smoker (10–19/day) | 0.74 (0.65 to 0.84) |
| Heavy smoker (20+/day) | 0.66 (0.56 to 0.77) |
| Other baseline factors | |
| Manic depression or schizophrenia | 1.55 (1.25 to 1.92) |
| Type 2 diabetes | 1.35 (1.21 to 1.49) |
| Endometrial hyperplasia or polyp | 2.35 (1.83 to 3.01) |
| Polycystic ovarian disease | 1.98 (1.43 to 2.76) |
| Prior bowel cancer | 1.56 (1.13 to 2.17) |
| Prior breast cancer | 2.49 (2.22 to 2.79) |
For fractional polynomial terms and interactions see footnotes and figures 1–5.
*Breast cancer model also included terms for age (2 FP terms), BMI (2 FP terms), Townsend (2 FP terms) and interaction between age and family history.
†Adjusted HR evaluated at mean age in women.
‡Ovarian cancer model also included terms for age (2 FP terms), BMI (linear and positive), and interaction between age and family history.
§Uterine cancer model also included terms for age (2 FP terms), and BMI (1 FP term).
HRT, hormone replacement therapy.