Changes from baseline in trough FEV1 and ACQ-7 average score by visit, and asthma symptoms summarised throughout the treatment period
| QMF149 | MF | Treatment difference: QMF149–MF | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | n (%) | LS mean | SE | n (%) | LS mean | SE | LS mean | SE | 95% CI |
| Change from baseline in trough FEV1 by visit (L) | |||||||||
| Overall | 727 (100) | 0.07 | 0.023 | 746 (100) | −0.05 | 0.023 | 0.12*** | 0.014 | (0.09 to 0.15) |
| Week 4 | 709 (97.5) | 0.09 | 0.023 | 728 (97.6) | −0.04 | 0.023 | 0.13*** | 0.014 | (0.10 to 0.16) |
| Week 12 | 681 (93.7) | 0.08 | 0.024 | 693 (92.9) | −0.02 | 0.024 | 0.11*** | 0.016 | (0.08 to 0.14) |
| Week 26 | 643 (88.4) | 0.08 | 0.024 | 658 (88.2) | −0.04 | 0.024 | 0.12*** | 0.017 | (0.08 to 0.15) |
| Week 52 | 431 (59.3) | 0.07 | 0.025 | 443 (59.4) | −0.07 | 0.025 | 0.14*** | 0.018 | (0.11 to 0.18) |
| Week 68 | 176 (24.2) | 0.06 | 0.028 | 171 (22.9) | −0.05 | 0.028 | 0.10*** | 0.026 | (0.05 to 0.15) |
| Final visit | 674 (92.7) | 0.06 | 0.025 | 699 (93.7) | −0.07 | 0.024 | 0.12*** | 0.018 | (0.09 to 0.16) |
| Change from baseline in ACQ-7 score by visit | |||||||||
| Overall | 728 (100) | −0.49 | 0.049 | 745 (100) | −0.29 | 0.049 | −0.19*** | 0.028 | (−0.25 to −0.14) |
| Week 4 | 709 (97.4) | −0.35 | 0.049 | 734 (98.5) | −0.15 | 0.049 | −0.20*** | 0.031 | (−0.26 to −0.14) |
| Week 12 | 679 (93.3) | −0.45 | 0.050 | 697 (93.6) | −0.24 | 0.050 | −0.21*** | 0.034 | (−0.28 to −0.15) |
| Week 26 | 648 (89.0) | −0.50 | 0.051 | 660 (88.6) | −0.38 | 0.051 | −0.13*** | 0.035 | (−0.20 to −0.06) |
| Week 52 | 432 (59.3) | −0.52 | 0.052 | 447 (60.0) | −0.35 | 0.052 | −0.17*** | 0.038 | (−0.24 to −0.10) |
| Week 68 | 178 (24.5) | −0.55 | 0.056 | 173 (23.2) | −0.32 | 0.057 | −0.23*** | 0.050 | (−0.33 to −0.13) |
| Final visit | 675 (92.7) | −0.55 | 0.052 | 687 (92.2) | −0.32 | 0.052 | −0.22*** | 0.040 | (−0.30 to −0.14) |
| Percentage of days with no asthma symptoms during | |||||||||
| Morning | 730 | 22.3 | 2.17 | 746 | 18.4 | 2.17 | 3.9*** | 1.20 | (1.5 to 6.3) |
| Daytime | 731 | 27.1 | 2.96 | 749 | 19.5 | 2.95 | 7.7*** | 1.63 | (4.5 to 10.9) |
| Night-time | 730 | 23.6 | 2.69 | 746 | 17.3 | 2.68 | 6.3*** | 1.49 | (3.4 to 9.2) |
***p≤0.001. The ACQ-7 score ranges from 0=good control of asthma to 6=very poor control of asthma.
ACQ-7, Asthma Control Questionnaire; FEV1, forced expiratory volume in 1 s; LS, least squares; MF, mometasone furoate; SE, standard error.