The HR of CKD in 2338 patients with schizophrenia for comorbidities and NSAIDs use during the 3-year follow-up period
| Variable | Number of patients | Crude HR (95% CI) | Adjusted HR* (95% CI) | Adjusted HR† (95% CI) | Adjusted HR‡ (95% CI) |
|---|---|---|---|---|---|
| Comorbidity | |||||
| Hypertension | 420 | ||||
| <65 years old | 293 | 1 | 1 | 1 | 1 |
| ≥65 years old | 127 | 2.00 (1.23 to 3.25)§ | 1.85 (1.13 to 3.03)§ | 1.59 (0.96 to 2.63) | 1.54 (0.93 to 2.56) |
| Diabetes mellitus | 218 | ||||
| <65 years old | 173 | 1 | 1 | 1 | 1 |
| ≥65 years old | 45 | 3.83 (2.06 to 7.12)¶ | 3.66 (1.93 to 6.96)¶ | 2.56 (1.26 to 5.16)§ | 2.52 (1.25 to 5.09)§ |
| Dyslipidaemia | 272 | ||||
| <65 years old | 236 | 1 | 1 | 1 | 1 |
| ≥65 years old | 36 | 2.52 (1.13 to 5.65) | 2.54 (1.09 to 5.92)§ | 1.78 (0.76 to 4.15) | 1.90 (0.80 to 4.53) |
| Heart disease | 343 | ||||
| <65 years old | 247 | 1 | 1 | 1 | 1 |
| ≥65 years old | 96 | 2.53 (1.50 to 4.30)¶ | 2.46 (1.44 to 4.20)¶ | 1.69 (0.96 to 2.99) | 1.70 (0.96 to 3.00) |
| Medication | |||||
| NSAIDs use | 960 | ||||
| <65 years old | 835 | 1 | 1 | 1 | 1 |
| ≥65 years old | 125 | 2.82 (1.84 to 4.30)¶ | 2.82 (1.84 to 4.30)¶ | 1.83 (1.13 to 2.97)§ | 1.83 (1.13 to 2.97)§ |
*Adjusted HR Adjusted for NSAIDs use.
†Adjusted HR Adjusted for hypertension, diabetes mellitus, dyslipidaemia and heart disease.
‡Adjusted HR Adjusted for hypertension, diabetes mellitus, dyslipidaemia, heart disease and NSAIDs use.
§p<0.05 for comparison between patients with two groups.
¶p<0.001 for comparison between patients with two groups.
NSAIDs, non-steroidal anti-inflammatory drugs.