Demographics and descriptive characteristics
| Characteristic | Total cohort (n=550) | TACS=2 (n=196) | TACS=3 (n=209) | TACS=4 or 5 (n=145) | p Value |
|---|---|---|---|---|---|
| Sex, n (%) | 0.004* | ||||
| Female | 429 (78.0) | 162 (82.7) | 168 (80.4) | 99 (68.3) | |
| Male | 121 (22.0) | 34 (17.3) | 41 (19.6) | 46 (31.7) | |
| Race, n (%) | 0.821 | ||||
| White | 485 (96.0) | 175 (95.6) | 179 (96.8) | 131 (95.6) | |
| Non-white | 20 (4.0) | 8 (4.4) | 6 (3.2) | 6 (4.4) | |
| MS subtype, n (%) | 0.005* | ||||
| Relapsing–remitting | 230 (48.9) | 102 (59.3) | 80 (47.3) | 48 (36.9) | |
| 2° Progressive | 145 (30.8) | 48 (27.9) | 50 (29.6) | 47 (36.2) | |
| 1° Progressive | 27 (5.7) | 5 (2.9) | 8 (4.7) | 14 (10.7) | |
| Progressive-relapsing | 30 (6.4) | 6 (3.5) | 14 (8.3) | 10 (7.7) | |
| Unsure | 33 (7.0) | 11 (6.4) | 13 (7.7) | 9 (6.9) | |
| Current age, mean (SD) | 55.3 (9.2) | 53.4 (9.6) | 56.0 (9.1) | 57.0 (8.4) | <0.001* |
| Age of MS diagnosis, mean (SD) | 38.1 (9.5) | 36.6 (9.4) | 39.2 (9.6) | 38.7 (9.3) | 0.018* |
| Age of tremor onset, mean (SD) | 43.6 (11.4) | 41.8 (11.6) | 44.4 (11.0) | 45.0 (11.3) | 0.021* |
| Duration of MS, mean (SD) | 17.1 (8.4) | 16.7 (8.2) | 16.8 (7.9) | 18.3 (9.2) | 0.146 |
| Duration of tremor, mean (SD) | 11.6 (8.8) | 11.2 (8.3) | 11.6 (8.9) | 12.1 (9.5) | 0.702 |
| Family history of tremor, n (%) | 84 (15.5) | 30 (15.7) | 34 (16.4) | 20 (14.1) | 0.845 |
| Patient Determined Disease Step (IQR) | 5 (3, 6) | 4 (2, 5) | 5 (3, 6) | 6 (4, 6) | <0.001* |
*p<0.05.
MS, multiple sclerosis; TACS, Tremor and Coordination Scale.