Description and application of quality criteria 4–6 in studies satisfying criteria 1–3
| Mortality outcomes reported | CKD outcomes reported | For either outcome | |||||
|---|---|---|---|---|---|---|---|
| Paper | N | Clinical setting | By pre-AKI baseline | By post-AKI recovery | By pre-AKI function | By post-AKI recovery | Timing considered |
| Hoste et al27 | 82 | ITU | N | N | – | – | – |
| Lopes et al28 | 61 | ITU | N | N | – | – | – |
| Manns et al 29 | 66 | ITU | N | N | – | – | – |
| Schiffl and Fischer11 | 226 | ITU | CKD excluded | Y | – | – | – |
| Triverio et al17 | 95 | ITU | Y | Y | – | – | – |
| Bucaloiu et al12 | 1610 | Unselected | CKD excluded | Recovered only | CKD excluded | Recovered only | – |
| Hsu et al13 | 782 | Unselected | CKD only | N | N | N | – |
| Ishani et al18 | 7197 | Unselected | Y by code alone | N | Y by code alone | N | – |
| Jones et al14 | 719 | Unselected | CKD excluded | Recovered only | CKD excluded | Recovered only | – |
| Lafrance and Miller19 | 82 711 | Unselected | Y | Y | – | – | Sensitivity analysis excluding first 6 months |
| Lo et al30 | 343 | Unselected | N (excluded only if eGFR <45) | N | – | – | – |
| Ng et al31 | 262 | Unselected | N | N | – | – | – |
| Ponte et al21 | 177 | Unselected | N (Cr >1.4 excluded) | Y | – | – | – |
| Wald et al32 | 41 327 | Unselected | N | N | N | N | – |
| Gupta et al33 | 143 | Cardiac | N | N | – | – | – |
| Kimura et al34 | 81 | Cardiac | N | N | – | – | – |
| Lindsay et al35 | 179 | Cardiac | Y | N | – | – | – |
| Maioli et al15 | 167 | Cardiac | CKD only | Y | – | – | – |
| Rihal et al36 | 185 | Cardiac | N | N | – | – | – |
| Roghi et al37 | 106 | Cardiac | N | N | – | – | – |
| Brown et al22 | 1886 | Postoperative | N | Y | – | – | – |
| Coca et al23 | 6257 | Postoperative | N | Y | – | – | – |
| Ishani et al8 | 4053* | Postoperative | N | N | N | N | Changing HRs for mortality and CKD outcomes in time intervals |
| Kheterpal et al16 | 101 | Postoperative | CKD excluded | N | – | – | – |
| Loef et al24 | 145 | Postoperative | N | Y | – | – | – |
| Luckraz et al38 | 53 | Postoperative | N | N | – | – | – |
| Mehta et al25 | 2083 | Postoperative | N (excluded only Cr>2) | Y | – | – | – |
| Swaminathan et al39 | 1113 | Postoperative | N | N† | – | – | – |
| Van Kuijk et al26 | 120 | Postoperative | N | N | CKD excluded | Y | – |
| Wu et al20 | 4393 | Postoperative | Y by GFR>/<45 | Y | Y by GFR>/<45 | Y | – |
*19 779 in total, 4053 of which had >50% cr rise.
†Outcomes by rate of fall of cr over a 24 h rather than a recovery variable.
–, Outcome not addressed by study; AKI, acute kidney injury; CKD, chronic kidney disease; Cr, creatinine; eGFR, estimated glomerular filtration rate; ITU, intensive therapy unit;; N, outcome addressed but not per quality criterion.