| CRF | Thyroid cancer patient group only |
Laboratory clinical test and urine test Biomarker testing such as BRAF mutation Sonography, ECG and X-rays Preoperative laboratory test 5. Report on surgery and pathology
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| Core variables | All subjects |
Demographic information: age, education, marital status and social/living status Disease history: hypertension, diabetes, dyslipidaemia, cerebrovascular attacks, ischaemic heart disease, lung tuberculosis, benign thyroid disease (hyperthyroidism, hypothyroidism), gastric ulcer/gastritis, duodenal ulcer, colon polyp, acute liver disease, chronic liver disease, fatty liver, chronic obstructive pulmonary disease, chronic bronchitis, asthma, other allergy, gout, osteoarthritis, osteoporosis, cataract, glaucoma, depression, periodontal disease, prostate hypertrophy, fracture, site-specific cancer Medication history: aspirin, non-steroidal anti-inflammatory drugs, acetaminophen, others, vitamin supplements including vitamin E, calcium, Fe, glucosamine, ginseng and other medications Occupational history Family information: family history of disease and general information about family members Anthropometric information: current and past weight and height Lifestyle factors: active and passive cigarette smoking history, alcohol consumption history, sleep and physical activity Female reproductive factors: menarche, menopause, pregnancy, pregnancy outcome, children, delivery, breast feeding, abortion, oral contraceptives, postmenopausal hormone replacement therapy, surgical procedures of hysterectomy and oophorectomy Dietary habits and Food Frequency Questionnaires Health examination: blood pressure, total cholesterol, triglyceride, fasting blood sugar, serum creatinine, blood urea nitrogen, albumin, glutamate–oxaloacetate transaminase, glutamate–pyruvate transaminase, haemoglobin, haematocrit, white blood cell count, platelet
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| Additional variables for each group | Thyroid cancer patients and healthy participants in SNU-HEXA |
Additional medical history: the route of thyroid cancer diagnosis (symptoms, cancer screening or other), thyroiditis, thyroid adenoma, chronic hepatitis (B, C, A), systemic lupus erythematosus, chronic kidney disease, benign breast disease, uterine myoma and polycystic ovary, information on Helicobacter pylori infection, and average number of colds Thyroid-related drug history: thyroid medication, steroid, retinol, osteoporosis-treatment drugs Additional family history: thyroid adenoma, colon polyp, familial polyposis, chronic liver disease Environmental toxicant information: information on exposure to a newly constructed house, flooring material in a house, smelling of a new house, use of new furniture, internal flowerpots, ventilation by season, internal heating and air conditioning Environmental pollutant exposure such as incineration plant, cattle shed, etc, the number of lane and location of nearest lane from house, car driving history, use of pesticide and waterproof clothes Exposure to radiation and electromagnetic fields: medical and occupational radiation exposure, use of microwave oven and electric devices Exposure to chemical compounds: use of cosmetics, perfumes, nail polish, air freshener, deodorant, detergent, hair spray, hair colouring, occupational exposure to pesticides, dry cleaning, detergent use, painting, disinfectant and other hazardous chemicals including butadiene, acrylamide, benzene, ethylenoxide, bisphenolA, TCE, PCB, dioxin Other: coated cookware, materials of drinking water containers, use of instant, canned, plastic packaged, bottled, or vinyl-wrapped foods Socioeconomic stress: Score (visual analogue scale) of depression, stress, health status Additional testing related to thyroid hormones
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| Healthy participants pooled from KNHANES |
Exposure to occupational hazardous chemicals Measurement: vitamin D, parathyroid hormone, ALP, free thyroxine, thyrotropin, anti-thyroid peroxidase antibody, calcitonin, total and ionised calcium, phosphorus, 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3, hepatitis B surface antigen/antibody, anti-hepatitis C virus and HIV
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| Healthy participants pooled from KoGES-HEXA |
Additional disease histories Semiquantitative diet questionnaire and dietary habits
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