Risk of arterial thromboembolism* within 30 days following admission for pneumonia, by atrial fibrillation status
| No AF | AF | |
|---|---|---|
| Overall | ||
| Cumulative incidence, % | 3.6 (3.1 to 3.4) | 5.2 (4.7 to 5.7) |
| HRs | ||
| Crude | 1.00 (ref) | 1.61 (1.46 to 1.78) |
| Adjusted for CHA2DS2-VASc† | 1.00 (ref) | 1.06 (0.96 to 1.18) |
| Vitamin K antagonists | ||
| Cumulative incidence, % | ||
| Non-users | 3.2 (3.1 to 3.4) | 5.7 (5.1 to 6.4) |
| Users | 4.2 (3.4 to 5.0) | 4.3 (3.7 to 5.0) |
| HRs | ||
| Non-user | 1.00 (ref) | 1.00 (ref) |
| Users, Crude | 1.29 (1.05 to 1.59) | 0.74 (0.61 to 0.90) |
| Adjusted for CHA2DS2-VASc† | 0.97 (0.79 to 1.20) | 0.74 (0.61 to 0.91) |
| Aspirin | ||
| Cumulative incidence, % | ||
| Non-users | 2.9 (2.8 to 3.0) | 5.3 (4.8 to 5.9) |
| Users | 4.8 (4.5 to 5.2) | 5.0 (4.3 to 5.8) |
| HRs | ||
| Non-users | 1.00 (ref) | 1.00 (ref) |
| Users, crude | 1.69 (1.55 to 1.84) | 0.94 (0.78 to 1.14) |
| Adjusted for CHA2DS2-VASc† | 0.96 (0.88 to 1.06) | 0.83 (0.68 to 1.01) |
Cumulative incidence values were computed with non-stroke associated death as a competing risk.
95% CIs are presented in parentheses.
*Defined as a diagnostic code for ischaemic stroke, unspecified stroke, thrombosis, or embolism in arteries of the extremities, mesenteric arteries, or unspecified arteries assigned during index admission or subsequent admissions.
†Adjusted for prevalence of the risk factors included in the CHA2DS2-VASc-score (ie, congestive heart failure, hypertension, age, diabetes, previous stroke, vascular disease and sex).
AF, atrial fibrillation; HR, hazard ratio.