Pooled ORs and 95% CIs of overall and subgroup meta-analysis, heterogeneity test and sensitivity analysis in the codon 420 polymorphism
| Genetic model | Meta-analysis | Sensitivity analysis | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | Ph | I2 (95% CI; %) | OR (95% CI) | Ph | I2 (95% CI; %) | |
| Codon 420 (overall) | ||||||
| Lys vs Thr | 1.18 (0.95 to 1.46) | 0.05 | 56 (0 to 82) | 1.11 (0.88 to 1.40) | 0.10 | 49 (0 to 81) |
| Lys/Lys vs Thr/Thr | 1.11 (0.74 to 1.67) | 0.53 | 0 (0 to 75) | 1.00 (0.65 to 1.54) | 0.73 | 0 (0 to 79) |
| Lys/Thr vs Thr/Thr | 1.29 (0.95 to 1.76) | 0.02 | 63 (11 to 85) | 1.17 (0.86 to 1.58) | 0.08 | 52 (0 to 82) |
| Lys/Thr+Lys/Lys vs Thr/Thr | 1.29 (0.94 to 1.76) | 0.01 | 66 (19 to 86) | 1.16 (0.86 to 1.57) | 0.07 | 54 (0 to 83) |
| Codon 420 (Asian) | ||||||
| Lys vs Thr | 1.49 (1.19 to 1.85) | 0.37 | 0 (0 to 90) | 1.48 (1.07 to 2.05) | 0.16 | 50 (NA) |
| Lys/Lys vs Thr/Thr | 2.08 (0.76 to 5.69) | 0.76 | 0 (0 to 90) | 1.35 (0.25 to 7.12) | 0.74 | 0 (NA) |
| Lys/Thr vs Thr/Thr | 1.80 (1.36 to 2.38) | 0.35 | 5 (0 to 90) | 1.67 (1.14 to 2.43) | 0.19 | 42 (NA) |
| Lys/Thr+Lys/Lys vs Thr/Thr | 1.81 (1.37 to 2.39) | 0.31 | 14 (0 to 91) | 1.67 (1.15 to 2.43) | 0.17 | 47 (NA) |
| Codon 420 (Caucasian) | ||||||
| Lys vs Thr | 0.98 (0.82 to 1.18) | 0.48 | 0 (0 to 90) | NA | NA | NA |
| Lys/Lys vs Thr/Thr | 0.98 (0.63 to 1.53) | 0.40 | 0 (0 to 90) | NA | NA | NA |
| Lys/Thr vs Thr/Thr | 0.97 (0.76 to 1.25) | 0.53 | 0 (0 to 90) | NA | NA | NA |
| Lys/Thr+Lys/Lys vs Thr/Thr | 0.97 (0.77 to 1.23) | 0.52 | 0 (0 to 90) | NA | NA | NA |
NA, not available; Ph, p value for heterogeneity.