Pooled ORs and 95% CIs of overall and subgroup meta-analysis, heterogeneity test and sensitivity analysis in the codon 416 polymorphism
| Genetic model | Meta-analysis | Sensitivity analysis | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | Ph | I2 (95% CI; %) | OR (95% CI) | Ph | I2 (95% CI; %) | |
| Codon 416 (overall) | ||||||
| Glu vs Asp | 1.10 (0.97 to 1.26) | 0.35 | 11 (0 to 77) | 1.05 (0.91 to 1.22) | 0.45 | 0 (0 to 79) |
| Glu/Glu vs Asp/Asp | 1.10 (0.80 to 1.50) | 0.59 | 0 (0 to 75) | 1.10 (0.79 to 1.52) | 0.45 | 0 (0 to 79) |
| Glu/Asp vs Asp/Asp | 1.11 (0.82 to 1.50) | 0.08 | 50 (0 to 80) | 0.97 (0.76 to 1.24) | 0.52 | 0 (0 to 79) |
| Glu/Asp+Glu/Glu vs Asp/Asp | 1.14 (0.86 to 1.51) | 0.10 | 46 (0 to 79) | 1.02 (0.80 to 1.29) | 0.42 | 0 (0 to 79) |
| Codon 416 (Asian) | ||||||
| Glu vs Asp | 1.22 (0.99 to 1.51) | 0.47 | 0 (0 to 90) | 1.12 (0.83 to 1.52) | 0.35 | 0 (NA) |
| Glu/Glu vs Asp/Asp | 1.30 (0.67 to 2.55) | 0.87 | 0 (0 to 90) | 1.48 (0.61 to 3.60) | 0.79 | 0 (NA) |
| Glu/Asp vs Asp/Asp | 1.32 (0.84 to 2.05) | 0.09 | 59 (0 to 88) | 1.06 (0.72 to 1.54) | 0.29 | 11 (NA) |
| Glu/Asp+Glu/Glu vs Asp/Asp | 1.36 (1.04 to 1.78) | 0.13 | 51 (0 to 86) | 1.10 (0.76 to 1.58) | 0.29 | 11 (NA) |
| Codon 416 (Caucasian) | ||||||
| Glu vs Asp | 1.04 (0.88 to 1.22) | 0.27 | 24 (0 to 92) | NA | NA | NA |
| Glu/Glu vs Asp/Asp | 1.04 (0.73 to 1.49) | 0.21 | 36 (0 to 80) | NA | NA | NA |
| Glu/Asp vs Asp/Asp | 0.91 (0.66 to 1.26) | 0.42 | 0 (0 to 90) | NA | NA | NA |
| Glu/Asp+Glu/Glu vs Asp/Asp | 0.96 (0.70 to 1.31) | 0.28 | 21 (0 to 92) | NA | NA | NA |
NA, not available; Ph, p value for heterogeneity.