The basic characteristics of the included studies
| First author (year) | Country (ethnicity) | Participants | Cases source | Cases age (mean±SD, year) | HWE (p value*) | ||
|---|---|---|---|---|---|---|---|
| Cases | Controls | Codon 420 | Codon 416 | ||||
| Ye WZ (2001) | France (Caucasian) | 237 | 143 | Hospital | 63.00±11.00 | 0.730 | 0.710 |
| Klupa T (1999) | America (Caucasian) | 215 | 163 | Population | 62.30±5.40 | 0.841 | 0.811 |
| Malecki MT (2002) | Poland (Caucasian) | 231 | 162 | Population | 57.10±11.40 | 0.148 | 0.081 |
| Shao XJ (2012) | China (Asian) | 105 | 105 | Hospital | 60.67±11.69 | 0.223 | 1.000 |
| Ren W (2003) | China (Asian) | 201 | 110 | Population | 52.65±12.07 | 0.372 | 0.846 |
| Hirai M (1998) | Japan (Asian) | 202 | 199 | Population | NR | 0.0001 | 0.025 |
*p Value for the HWE in the control group.
HWE, Hardy-Weinberg equilibrium; NR, not reported.