Potential isotretinoin exposed pregnancies per exposure interval
| Isotretinoin exposure interval* | Exposed pregnancies (N=203 962) | Exposed pregnancies per 10 000 pregnancies (95% CI) | Median number of days exposed per pregnancy (range) |
|---|---|---|---|
| 30 days before conception (30 days period) | 23 | 1.1 (0.7 to 1.7) | 24 (3–30) |
| 1st trimester (90 days period) | 28 | 1.4 (0.9 to 2.0) | 31 (3–88) |
| 2nd trimester (90 days period) | 25 | 1.2 (0.8 to 1.8) | 57 (1–90) |
| 3rd trimester (90–103 days period) | 26 | 1.3 (0.9 to 1.8) | 62 (1–103) |
| During pregnancy (270 days period) | 45 | 2.2 (1.6 to 2.9) | 63 (3–236) |
| 30 days before or during pregnancy (300 days period) | 51 | 2.5 (1.9 to 3.3) | 63 (7–236) |
| 30 days before or during 1st trimester (120 days period) | 35 | 1.7 (1.2 to 2.4) | 32 (7–114) |
*Categories are not mutually exclusive but indicate the number of pregnancies exposed to isotretinoin during that exposure interval.