Table 4

Gene–environment interactions of XRCC1 and OGG1 polymorphisms together with smoking and alcohol drinking on cholangiocarcinoma risk in Khon Kaen, Thailand

SmokingCasesControlsSmokingCasesControls
XRCC1Use of alcoholnnOR*95% CIp ValueOGG1Use of alcoholnnOR*95% CIp Value
G399AAll cigarettes smoking0.87†C326GAll cigarettes smoking0.54†
 GG Non-smoker22711.0 CC Non-smoker14551.0
 GA Non-smoker48991.50.82 to 2.790.18 CG Non-smoker491221.50.77 to 2.990.22
 AA Non-smoker2110.60.11 to 2.740.47 GG Non-smoker11–––
 GG Smoker40782.81.30 to 5.910.01 CC Smoker20403.11.17 to 8.380.02
 GA Smoker46703.41.60 to 7.280.001 CG Smoker601074.31.79 to 10.210.001
 AA Smoker2101.20.21 to 6.290.86 GG Smoker141.50.14 to 15.440.74
G399AUnits of alcohol per month of all alcohol drinking0.80†C326GUnits of alcohol per month of all alcohol drinking0.74†
 GG Non-drinker16831.0 CC Non-drinker10651.0
 GA Non-drinker20334.41.81 to 10.830.001 CG Non-drinker998.12.30 to 28.360.001
 AA Non-drinker26339.23.65 to 23.21<0.001 GG Non-drinker15218.62.62 to 28.02<0.001
 GG <14221021.10.49 to 2.280.89 CC <14241301.30.55 to 3.200.52
 GA <1439358.83.76 to 20.71<0.001 CG <1446587.02.85 to 17.39<0.001
 AA <14333210.34.14 to 25.80<0.001 GG <14394111.24.18 to 30.17<0.001
 GG ≥141120.40.05 to 3.710.44 CC ≥1401–––
 GA ≥14232.80.31 to 25.410.36 CG ≥14117.70.29 to 26.730.22
 AA ≥14162.50.25 to 23.990.44 GG ≥14136.40.48 to 86.720.16

  • *Crude OR from matched case–control analysis.

  • †p Value for interaction.