Funding | No funding and not-for-profit funding will be considered as low RoB | For-profit funding and cofinanced funding will be considered high RoB. If funding is not reported, it will also be considered high RoB |
Conflict of interest | If conflict of interest is reported as ‘none,’ it will be considered low RoB | If conflict of interest is not reported as ‘none,’ it will be considered high RoB |
Flow chart | If a flow chart is publicly available, it will be considered low RoB | If a flow chart is not publicly available, it will be considered high RoB |
Number of study locations | It will be considered low RoB if more than one centre participated in the trial | It will be considered high RoB if only one centre participated in the trial, or if it is unclear how many centres participated |