Table 4

Risk of bias (RoB) components currently not included in the Cochrane RoB tool

RoB itemLow RoBHigh RoB
FundingNo funding and not-for-profit funding will be considered as low RoBFor-profit funding and cofinanced funding will be considered high RoB. If funding is not reported, it will also be considered high RoB
Conflict of interestIf conflict of interest is reported as ‘none,’ it will be considered low RoBIf conflict of interest is not reported as ‘none,’ it will be considered high RoB
Flow chartIf a flow chart is publicly available, it will be considered low RoBIf a flow chart is not publicly available, it will be considered high RoB
Number of study locationsIt will be considered low RoB if more than one centre participated in the trialIt will be considered high RoB if only one centre participated in the trial, or if it is unclear how many centres participated