Table 8

Proportions of patients per health state at the end of each year

	Very high risk	High risk	Medium risk	Low risk	Abstinence	Death*	Serious events†
Year 1
NMF	0.18	0.17	0.12	0.40	0.10	0.01	0.02
PS	0.26	0.27	0.14	0.22	0.08	0.01	0.02
	Very high risk/high risk		Medium risk	Low risk/abstinence (controlled drinking state)		Death*	Serious events†
Year 2
NMF	0.38		0.07	0.50		0.01	0.04
PS	0.56		0.07	0.30		0.02	0.04
Year 3
NMF	0.40		0.04	0.47		0.02	0.06
PS	0.58		0.05	0.28		0.02	0.07
Year 4
NMF	0.42		0.03	0.44		0.03	0.07
PS	0.60		0.03	0.25		0.03	0.09
Year 5
NMF	0.44		0.03	0.40		0.04	0.09
PS	0.60		0.02	0.22		0.04	0.11

*Absorbing state.
†Serious event state (‘post-event state’): Ischaemic heart disease; Haemorrhagic stroke; Ischaemic stroke; Cirrhosis of the liver; Pancreatitis.
NMF, nalmefene plus psychosocial support; PS, psychosocial support alone.