Comparison of baseline characteristics of patients in CPRD validation cohort and QResearch comparison cohort
| CPRD | CPRD | QResearch | QResearch | |
|---|---|---|---|---|
| Men (%) | Women (%) | Men (%) | Women (%) | |
| Total | 1 588 803 | 1 682 709 | 3 304 145 | 3 454 504 |
| Age band (years) | ||||
| 25–34 | 427 975 (26.9) | 467 192 (27.8) | 1 083 589 (32.8) | 1 179 742 (34.2) |
| 35–44 | 396 680 (25.0) | 364 150 (21.6) | 814 988 (24.7) | 731 089 (21.2) |
| 45–54 | 294 274 (18.5) | 277 663 (16.5) | 558 553 (16.9) | 516 188 (14.9) |
| 55–64 | 212 817 (13.4) | 211 636 (12.6) | 390 229 (11.8) | 389 266 (11.3) |
| 65–74 | 148 180 (9.3) | 164 172 (9.8) | 267 997 (8.1) | 298 847 (8.7) |
| 75+ years | 108 877 (6.9) | 197 896 (11.8) | 188 789 (5.7) | 339 372 (9.8) |
| Mean Townsend score (SD) | −0.5 (3.2) | −0.5 (3.2) | 0.3 (3.6) | 0.2 (3.6) |
| Care home resident | 1407 (0.1) | 3466 (0.2) | 2983 (0.1) | 7411 (0.2) |
| Ethnicity recorded | 587 879 (37.0) | 658 835 (39.2) | 1 859 462 (56.3) | 2 077 181 (60.1) |
| White or not recorded | 1 515 113 (95.4) | 1 602 212 (95.2) | 3 010 061 (91.1) | 3 149 618 (91.2) |
| Indian | 16 442 (1.0) | 16 025 (1.0) | 56 156 (1.7) | 50 406 (1.5) |
| Pakistani | 6606 (0.4) | 6146 (0.4) | 30 632 (0.9) | 23 405 (0.7) |
| Bangladeshi | 2419 (0.2) | 1688 (0.1) | 23 017 (0.7) | 17 450 (0.5) |
| Other Asian | 10 795 (0.7) | 11 873 (0.7) | 32 513 (1.0) | 36 886 (1.1) |
| Caribbean | 4989 (0.3) | 6425 (0.4) | 25 782 (0.8) | 32 953 (1.0) |
| Black African | 12 883 (0.8) | 14 771 (0.9) | 51 980 (1.6) | 56 528 (1.6) |
| Chinese | 2914 (0.2) | 4176 (0.2) | 16 084 (0.5) | 23 043 (0.7) |
| Other ethnic group | 16 642 (1.0) | 19 393 (1.2) | 57 920 (1.8) | 64 215 (1.9) |
| Smoking status recorded | 1 442 088 (90.8) | 1 595 538 (94.8) | 2 943 405 (89.1) | 3 219 598 (93.2) |
| Non-smoker | 613 833 (38.6) | 834 721 (49.6) | 1 449 694 (43.9) | 1 973 691 (57.1) |
| Ex-smoker | 252 873 (15.9) | 222 615 (13.2) | 611 837 (18.5) | 545 125 (15.8) |
| Light smoker (1–9/day) | 104 466 (6.6) | 109 864 (6.5) | 472 614 (14.3) | 384 482 (11.1) |
| Moderate smoker (10–19/day) | 183 000 (11.5) | 179 391 (10.7) | 223 631 (6.8) | 202 776 (5.9) |
| Heavy smoker (20+/day) | 142 438 (9.0) | 87 474 (5.2) | 185 629 (5.6) | 113 524 (3.3) |
| Smoker amount not recorded | 145 478 (9.2) | 161 473 (9.6) | 0 (0.0) | 0 (0.0) |
| Alcohol status recorded | 1 238 110 (77.9) | 1 379 002 (82.0) | 2 584 335 (78.2) | 2 834 426 (82.1) |
| Non-drinker | 163 633 (10.3) | 318 880 (19.0) | 583 752 (17.7) | 1 035 692 (30.0) |
| Trivial <1 u/day | 460 091 (29.0) | 726 851 (43.2) | 782 985 (23.7) | 1 144 469 (33.1) |
| Light 1–2 u/day | 411 261 (25.9) | 290 547 (17.3) | 481 674 (14.6) | 402 750 (11.7) |
| Moderate 3–6 u/day | 166 328 (10.5) | 36 763 (2.2) | 648 549 (19.6) | 237 679 (6.9) |
| Heavy 7–9 u/day | 19 612 (1.2) | 2853 (0.2) | 54 083 (1.6) | 7152 (0.2) |
| Very heavy >/day | 17 185 (1.1) | 3108 (0.2) | 24 468 (0.7) | 5195 (0.2) |
| Family history | ||||
| Family history of CHD | 68 805 (4.3) | 80 985 (4.8) | 326 995 (9.9) | 417 537 (12.1) |
| Family history of diabetes | 96 810 (6.1) | 132 390 (7.9) | 357 109 (10.8) | 487 397 (14.1) |
| Family history of osteoporosis | 880 (0.1) | 10 062 (0.6) | 1655 (0.1) | 17 529 (0.5) |
| Family history of kidney disease | 1253 (0.1) | 1586 (0.1) | 2034 (0.1) | 2769 (0.1) |
| Clinical values recorded | ||||
| BMI recorded | 1 268 235 (79.8) | 1 481 918 (88.1) | 2 553 514 (77.3) | 2 857 742 (82.7) |
| Mean BMI (SD) | 29.6 (6.8) | 28.2 (7.0) | 29.4 (6.8) | 28.2 (7.0) |
| SBP recorded | 1 359 560 (85.6) | 1 590 226 (94.5) | 2 755 733 (83.4) | 3 190 390 (92.4) |
| Mean SBP(SD) | 133.1 (23.6) | 128.6 (22.7) | 132.2 (18.3) | 127.1 (20.8) |
| Cholesterol/HDL ratio recorded | 587 865 (37.0) | 606 035 (36.0) | 1 323 503 (40.1) | 1 368 180 (39.6) |
| Mean cholesterol ratio (SD) | 4.4 (1.4) | 3.7 (1.2) | 4.4 (1.4) | 3.7 (1.2) |
| Platelets recorded | 223 461 (14.1) | 382 799 (22.7) | 478 596 (14.5) | 829 702 (24.0) |
| Platelets <150 or >480 | 11 051 (0.7) | 13 282 (0.8) | 23 479 (0.7) | 27 009 (0.8) |
| Creatinine recorded | 811 779 (51.1) | 997 118 (59.3) | 1 714 337 (51.9) | 2 053 036 (59.4) |
| Mean creatinine (SD) | 96.7 (32.5) | 79.7 (24.1) | 95.5 (30.7) | 78 (23.7) |
BMI, body mass index; CPRD, Clinical Research Data Link; CHD, coronary heart disease; HDL, high-density lipoprotein; SBP, systolic blood pressure.