Table 2

Predictors of in-hospital mortality in HIV-infected adults with CAP and SP-CAP

	CAP						SP-CAP
	Univariate analysis			Multivariable analysis			Univariate analysis			Multivariable analysis
	OR	95% Confidence limit	p Value	OR	95% Confidence limit	p Value	OR	95% Confidence limit	p Value	OR	95% Confidence limit	p Value
Pneumococcal aetiology (vs not)	0.806	0.378–1.719	0.5766
Bacteraemic pneumococcal pneumonia (vs not)	1.289	0.585–2.841	0.5285				5.37	0.655–44.055	0.12
Male (vs female)	1.083	0.527–2.225	0.8292				0.91	0.247–3.36	0.88
Age	1.028	0.992–1.065	0.1307				1.04	0.97–1.108	0.29	1.086	0.985–1.198	0.097
Cotrimoxazole prophylaxis (vs not)	0.211	0.028–1.603	0.1327				1.08	0.121–9.765	0.94
CD4 count	0.999	0.996–1.002	0.4752				0.998	0.992–1.005	0.58
HAART (vs not)	0.838	0.238–2.948	0.783				5.85	1.175–29.144	0.03
CURB65	1.137	0.782–1.654	0.5007				1.425	0.684–2.97	0.34
Copeptin	1.005	1.002–1.008	0.0013				1.005	1.001–1.009	0.0254
MR-proANP	1.005	1.003–1.008	<0.0001				1.008	1.001–1.014	0.0156
PCT	1.013	0.996–1.030	0.1226				1.018	0.993–1.043	0.1597
MR-proADM	1.260	1.123–1.412	<0.0001	1.196	1.011–1.414	0.0366	1.266	1.064–1.505	0.0076
Log₁₀ lytA rtPCR NP	1.284	0.985–1.672	0.0642	1.870	1.047–3.342	0.0345	2.262	1.086–4.712	0.03	2.104	0.952–4.65	0.0659

Pneumococcal and non-pneumococcal aetiology were defined according to composite diagnostic standard (pneumococci were detected by either blood culture, urine immunochromatographic BinaxNow Streptococcus pneumoniae test, good quality (ie, >25 neutrophils and <10 epithelial cells per high-power field) sputum Gram stain or culture, or whole blood lytA real-time (rt) PCR). ORs are reported as increase per single unit of the respective risk factor, for example, per year (age), per point (CURB65 score), per cell/µL (CD4 count).
CAP, community-acquired pneumonia; SP-CAP, pneumococcal pneumonia.