HRs of incident fatty liver by frequency of physical activity in never-moderate alcohol drinkers
| Frequency of engaging in physical activity (times/week) | ||||
|---|---|---|---|---|
| HR (95% CI) | ||||
| <1× | 1× | 2× | ≥3× | |
| Low-intensity physical activity | ||||
| Number of participants | 4900 | 728 | 516 | 1659 |
| Number of person-years | 21 679 | 3278 | 2269 | 7422 |
| Number of fatty liver cases | 804 | 108 | 88 | 255 |
| Incidence rates per 1000 person-years | 37 | 33 | 39 | 34 |
| Unadjusted | 1.00 | 0.89 (0.73 to 1.09) | 1.05 (0.84 to 1.31) | 0.93 (0.81 to 1.07) |
| Adjusted for age and gender | 1.00 | 0.87 (0.71 to 1.07) | 0.98 (0.78 to 1.22) | 0.86 (0.74 to 0.99) |
| Model 1* | 1.00 | 0.95 (0.78 to 1.17) | 1.00 (0.80 to 1.24) | 0.87 (0.75 to 1.01) |
| Model 2† | 1.00 | 0.91 (0.74 to 1.12) | 0.96 (0.77 to 1.20) | 0.82 (0.71 to 0.96) |
| Moderate-intensity physical activity | ||||
| Number of participants | 6699 | 478 | 318 | 308 |
| Number of person-years | 29 579 | 2200 | 1441 | 1428 |
| Number of fatty liver cases | 1117 | 67 | 41 | 30 |
| Incidence rates per 1000 person-years | 38 | 30 | 28 | 21 |
| Unadjusted | 1.00 | 0.81 (0.63 to 1.04) | 0.76 (0.55 to 1.03) | 0.56 (0.39 to 0.81) |
| Adjusted for age and gender | 1.00 | 0.81 (0.63 to 1.03) | 0.71 (0.52 to 0.97) | 0.52 (0.36 to 0.75) |
| Model 1* | 1.00 | 0.88 (0.69 to 1.13) | 0.74 (0.54 to 1.01) | 0.56 (0.39 to 0.81) |
| Model 2† | 1.00 | 0.87 (0.68 to 1.12) | 0.74 (0.54 to 1.01) | 0.56 (0.39 to 0.81) |
| Vigorous-intensity physical activity | ||||
| Number of participants | 6935 | 328 | 254 | 286 |
| Number of person-years | 30 641 | 1484 | 1181 | 1342 |
| Number of fatty liver cases | 1153 | 48 | 24 | 30 |
| Incidence rates per 1000 person-years | 38 | 32 | 20 | 22 |
| Unadjusted | 1.00 | 0.86 (0.64 to 1.15) | 0.54 (0.36 to 0.82) | 0.60 (0.42 to 0.86) |
| Adjusted for age and gender | 1.00 | 0.84 (0.63 to 1.12) | 0.54 (0.36 to 0.82) | 0.55 (0.38 to 0.79) |
| Model 1* | 1.00 | 0.87 (0.65 to 1.16) | 0.58 (0.39 to 0.88) | 0.54 (0.38 to 0.78) |
| Model 2† | 1.00 | 0.86 (0.64 to 1.15) | 0.57 (0.38 to 0.86) | 0.55 (0.38 to 0.79) |
The HRs of all covariates in model 2 are presented in online supplementary table S2. Italic numbers indicate p<0.05.
*Adjusted for age, gender, body mass index, alcohol consumption (never or low-moderate), smoking, family history of liver disease, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, hypertension, diabetes, dyslipidaemia and meat and vegetable intakes.
†Additional adjustment of model 1 for other intensity types of physical activity.