Search strategy performed in PubMed
| Items | Search terms | Number of citations |
|---|---|---|
| 1# | ((activated protein C[Title/Abstract]) OR xigris[Title/Abstract]) OR drotrecogin alfa[Title/Abstract] | 4460 |
| 2# | (sepsis[Title/Abstract]) OR septic shock[Title/Abstract] | 72 635 |
| 3# | (((mortality[Title/Abstract]) OR safety[Title/Abstract]) OR adverse events[Title/Abstract]) OR bleeding[Title/Abstract] | 875 580 |
| 1# AND 2# AND 3# | 531 |