Summary of the characteristics of the included studies
| Author (year) country | Knee loading variable | Structural progression measure | Follow-up time (months) | Number of patients (total/progressors/non-progressors) | Females (%) | Reference | |
|---|---|---|---|---|---|---|---|
| Miyazaki et al (2002) Japan | Peak KAM (unit: %BW×HT) | ≥1 grade according to Altman atlas | sq X-ray | 72 | 74/42/32 | 78 | 30 |
| Chang et al (2007) USA | Peak KAM (unit: %BW×HT) | ≥1 grade according to Altman atlas | sq X-ray | 18 | 56 (64*)/41/15 | 59 | 31 35* |
| Bennell et al (2011) Australia | Peak KAM (unit: %BW×HT) | ≥1 grade medial tibiofemoral cartilage defects | sq MRI | 12 | 138/45/93 | 56 | 29 |
| KAM impulse (unit: %BW×HT) | Cartilage volume loss (mm3) | q MRI | 144/NA/NA | ||||
| Woollard et al (2011) USA | Peak KAM (unit: Nm/kg)† | Cartilage volume loss (mm3) | q MRI | 12 | 13/6/7 | 23 | 32 |
| Henriksen et al (2013) Denmark | Peak overall knee compression force (unit: N) | Cartilage loss | sq MRI | 12 | 157/NA/NA | 89 | 33 |
| Median: 12 | Totals: 452/134/147 | Mean: 67 | |||||
*On request, the authors forwarded a conference abstract with additional data based on 64 subjects. The number of progressors/non-progressors was not available from that abstract.
†We converted the data into %BW×HT after requesting for body weight and height data from the authors.
KAM, knee adduction moment; BW, body weight; HT, height; q, quantitative; sq, semiquantitative grading; NA, non-applicable.