Incidence of anxiety disorders in traumatic brain injury patients with and without pre-existing hyperlipidaemia
| TBI with hyperlipidaemia | TBI without hyperlipidaemia | IRR* (95% CI) | Crude HR (95% CI) | Adjusted† HR (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | ADs | PY | IR | N | ADs | PY | IR | ||||
| Total | 1274 | 137 | 7217.41 | 189.82 | 2548 | 177 | 14890.15 | 118.87 | 1.60 (1.28 to 2.00)‡ | 1.58 (1.27 to 1.98)‡ | 1.58 (1.24 to 2.02)‡ |
| Age | |||||||||||
| ≤35 | 82 | 7 | 651.46 | 107.45 | 164 | 8 | 1335.06 | 59.92 | 1.79 (0.65 to 4.94) | 1.00 (ref.) | 1.00 (ref.) |
| 35–50 | 274 | 29 | 1779.58 | 162.96 | 548 | 36 | 3657.26 | 98.43 | 1.66 (1.02 to 2.70)$ | 1.47 (0.84 to 2.58) | 1.33 (0.75 to 2.33) |
| 50–65 | 399 | 53 | 2128.21 | 249.04 | 797 | 53 | 4471.10 | 118.54 | 2.10 (1.44 to 3.07)‡ | 1.87 (1.09 to 3.21)$ | 1.52 (0.88 to 2.64) |
| >65 | 519 | 48 | 2658.16 | 180.58 | 1039 | 80 | 5426.74 | 147.42 | 1.22 (0.86 to 1.75) | 1.82 (1.07 to 3.11)$ | 1.43 (0.82 to 2.49) |
| Gender | |||||||||||
| Male | 860 | 70 | 4925.39 | 142.12 | 1720 | 93 | 9997.31 | 93.03 | 1.53 (1.12 to 2.08)$ | 1.00 (ref.) | 1.00 (ref.) |
| Female | 414 | 67 | 2292.02 | 292.32 | 828 | 84 | 4892.85 | 171.68 | 1.70 (1.24 to 2.35)$ | 1.90 (1.52 to 2.37)‡ | 1.84 (1.47 to 2.30)‡ |
| Hypertension | |||||||||||
| No | 717 | 78 | 4517.91 | 172.65 | 2123 | 144 | 12891.99 | 111.70 | 1.55 (1.17 to 2.04)$ | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 557 | 59 | 2699.50 | 218.56 | 425 | 33 | 1998.16 | 165.15 | 1.32 (0.86 to 2.03) | 1.43 (1.12 to 1.82)$ | 1.16 (0.88 to 1.54) |
| Diabetes mellitus | |||||||||||
| No | 828 | 95 | 4995.69 | 190.16 | 2331 | 164 | 13814.23 | 118.72 | 1.60 (1.24 to 2.06)‡ | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 446 | 42 | 2221.72 | 189.04 | 217 | 13 | 1075.93 | 120.83 | 1.56 (0.84 to 2.91) | 1.14 (0.85 to 1.52) | 0.80 (0.58 to 1.10) |
| Cardiovascular disease | |||||||||||
| No | 1073 | 114 | 6119.97 | 186.28 | 2413 | 163 | 14189.06 | 114.88 | 1.62 (1.28 to 2.06)‡ | 1.00 (ref.) | 1.00 (ref.) |
| Yes | 201 | 23 | 1097.44 | 209.58 | 135 | 14 | 701.10 | 199.69 | 1.05 (0.54 to 2.04) | 1.47 (1.05 to 2.08)$ | 1.20 (0.83 to 1.75) |
‡p<0.001; $p<0.05.
*Estimated with Poisson regression.
†The model was adjusted by age, gender, hypertension, diabetes mellitus and cardiovascular disease.
ADs, anxiety disorders; IR, incidence rate, per 10 000 person-years; IRR, incidence rate ratio; PY, person-year; ref., reference group; TBI, traumatic brain injury.