Source | Number of patients | Protective | Conventional | Setting | Design | Duration of ventilation | PEEP(PV/CV) (cm H2O) | RM | Primary outcome | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
VT(ml/kg) | N | VT(ml/kg) | N | PV (h) | CV (h) | |||||||
Severgnini et al16 | 53 | 7 | 27 | 9 | 26 | Abdominal | P,R,NB,S | 3.2±1.1 | 3.7±1.3 | 10/0 | Yes | Pulmonary infection |
Futier et al17 | 400 | 6–8 | 200 | 10–12 | 200 | Abdominal | P,R,DB,M | 5.3±2.3 | 5.7±2.1 | 6–8/0 | Yes | Pneumonia |
Treschan et al14 | 101 | 6 | 50 | 12 | 51 | Abdominal | P,R,DB,S | 8.7±5.2 | 8.7±5.9 | 5/5 | Yes | Spirometry |
Weingarten 2009 | 40 | 6 | 20 | 10 | 20 | Abdominal | P,R,NB,S | 5.1±1.9 | 5.7±1.7 | 12/0 | Yes | Oxygenation |
Total | 594 | – | 297 | – | 297 | – | – | 5.7±3.3 | 6.0±3.3 | – | – | – |
CV, conventional ventilation; DB, double blinded; M, multicentre; NB, non-blinded; P, prospective; PEEP, positive end-expiratory pressure; PV, protective ventilation; R, randomised; RM, recruitment manoeuvre; S, single centre.