Multivariate regression for diastolic dysfunction in all patients excluding apical HCM
| LA volume >40 mL/m2 | E′<8 | E/E′>15 | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Multivariate analysis | ||||||
| Age (years) | 1.05 (1.03 to 1.07) | <0.001 | 1.04 (1.02 to 1.06) | <0.001 | ||
| Male sex | ||||||
| Indexed IVS (mm/m2) | 1.42 (1.24 to 1.62) | <0.001 | 1.17 (1.05–1.31) | 0.006 | ||
| RWT (per 0.3 units) | 2.40 (1.58 to 3.64) | <0.001 | ||||
| Moderate-to-severe MR | 6.10 (1.8 to 19.80) | 0.003 | 6.38 (1.45 to 28.19) | 0.01 | ||
| LV gradient >30 mm Hg | 2.04 (1.23 to 3.39) | 0.005 | 2.55 (1.42 to 4.53) | 0.001 | 4.66 (2.51 to 8.64) | <0.001 |
| Model adding genotype* | ||||||
| Age (years) | 1.05 (1.02 to 1.08) | <0.001 | 1.05 (1.01 to 1.08) | 0.005 | ||
| Male sex | 2.6 (1.65 to 3.82) | 0.001 | 0.38 (0.15 to 0.96) | 0.04 | ||
| Indexed IVS (mm/m2) | 1.50 (1.95 to 1.89) | <0.001 | ||||
| RWT (per 0.3 units) | ||||||
| Moderate-to-severe MR | 15.06 (1.7 to 130.55) | 0.01 | 7.58 (1.89 to 30.2) | 0.01 | ||
| LV gradient >30 mm Hg | 2.17 (1.01 to 4.76) | 0.05 | 2.89 (1.26 to 6.64) | 0.01 | 6.73 (2.67 to 19.61) | <0.001 |
| Gene mutation (s)* | 2.52 (1.14 to 5.57) | 0.02 | ||||
*On 166 patients.
IVS, interventricular septum; LV, left ventricle, MR, mitral regurgitation; RWT, relative wall thickness.