Crude and adjusted HRs for asthma in children born in Denmark between 1996 and 2009, according to prenatal exposure to local or systemic corticosteroids at any time during gestation.
| N | Crude HR (95% CI) | Adjusted HR (95% CI)* | |
|---|---|---|---|
| No corticosteroid use | 1.00 (ref) | 1.00 (ref) | |
| Systemic treatment | 5325 | 1.73 (1.62 to 1.85) | 1.54 (1.45 to 1.65) |
| 1 redeemed prescription | 3800 | 1.73 (1.61 to 1.87) | 1.60 (1.48 to 1.72) |
| ≥2 redeemed prescriptions | 1525 | 1.73 (1.53 to 1.95) | 1.42 (1.26 to 1.60) |
| Local treatment | 26 434 | 1.45 (1.40 to 1.50) | 1.45 (1.40 to 1.50) |
| Former maternal use | 162 949 | 1.36 (1.34 to 1.38) | 1.32 (1.30 to 1.34) |
*Adjusted for maternal age, maternal smoking, maternal use of antibiotics, paracetamol, PPIs or anti-inflammatory drugs, mode of delivery, birth year, birth weight, gestational age, birth order and gender.