Baseline clinical characteristics of the two study subgroups
| Variable | Anaemia (N=258) | Non-anaemic (N=603) | p Value |
|---|---|---|---|
| Age (years) | 76 [9] | 73 [11] | <0.001 |
| Female gender | 89 (34.5) | 170 (28.2) | 0.074 |
| Diabetes mellitus | 119 (46.1) | 191 (31.7) | <0.001 |
| Hypercholesterolaemia | 162 (62.8) | 407 (67.5) | 0.183 |
| Current or ex-smoking | 26 (10.1) | 62 (10.3) | 1.00 |
| Hypertension | 221 (85.7) | 503 (83.4) | 0.48 |
| Paroxysmal atrial fibrillation | 103 (39.9) | 229 (38.0) | 0.594 |
| Persistent atrial fibrillation | 22 (8.5) | 78 (12.9) | 0.081 |
| Permanent atrial fibrillation | 129 (50) | 294 (48.8) | 0.766 |
| CHA2DS2-VASc score >4 | 148 (57.4) | 235 (39.0) | <0.001 |
| HAS-BLED score ≥3 | 215 (83.3) | 441 (73.1) | 0.001 |
| History of peptic ulcer | 17 (6.6) | 27 (4.5) | 0.236 |
| History of cerebral haemorrhage | 4 (1.6) | 6 (1.0) | 0.497 |
| History of GI haemorrhage | 9 (3.5) | 12 (2.0) | 0.144 |
| History of heart failure | 69 (26.7) | 113 (18.7) | 0.011 |
| eGFR below 60 mL/min | 119 (52.2) | 175 (31.9) | <0.001 |
| Prior transient ischaemic attacks | 12 (4.7) | 30 (5.0) | 1.00 |
| Prior stroke | 36 (14.0) | 67 (11.1) | 0.252 |
| Prior MI | 76 (29.5) | 146 (24.2) | 0.126 |
| Prior PCI | 47 (18.2) | 100 (16.6) | 0.555 |
| Prior coronary bypass surgery | 47 (18.2) | 78 (12.9) | 0.057 |
| Proton pump inhibitors | 123 (47.7) | 189 (31.3) | <0.001 |
| Stable angina pectoris | 81 (31.4) | 289 (48.0) | <0.001 |
| ACS | 177 (68.6) | 313 (52.0) | <0.001 |
| Unstable angina pectoris | 53 (20.5) | 107 (17.7) | 0.34 |
| Non-ST-elevation MI | 83 (32.2) | 132 (21.9) | 0.002 |
| ST-elevation MI | 41 (15.9) | 74 (12.3) | 0.156 |
Continuous variables are presented as median [IQR], whereas categorical variables are presented as frequency (percentage).
ACS, acute coronary syndrome; eGFR, estimated glomerular filtration rate; GI, gastrointestinal; MI, myocardial infarction; PCI, percutaneous coronary intervention.