PPV and NPV of different asthma outcome measures
| ALSPAC asthma outcome | PPV (95% CI) | NPV (95% CI) |
|---|---|---|
| Single outcomes | ||
| Doctor diagnosis of asthma | 82.1% (63.1% to 93.9%) | 97.3% (92.4% to 99.4%) |
| Ever reported breathlessness | 51.3% (34.8% to 67.6%) | 94.1% (87.6% to 97.8%) |
| Ever reported wheezing | 36.1% (25.1% to 48.3%) | 100% (94.8% to 100%) |
| Wheezing reported on two or more occasions | 46.0% (31.8% to 60.7%) | 96.7% (90.7% to 99.3%) |
| Reported wheezing after age 3 | 47.2% (30.4% to 64.5%) | 91.4% (84.4% to 96.0%) |
| Ever reported a frequent wheeze | 50.0% (33.4% to 66.6%) | 93.2% (86.5% to 97.2%) |
| Reported a frequent wheeze after age 3 | 75.0% (50.9% to 91.3%) | 90.9% (84.3% to 95.4%) |
| Combinations of outcomes | ||
| Ever wheezed+ever breathless | 55.6% (38.1% to 72.1%) | 94.3% (88.0% to 97.9%) |
| Ever symptoms+doctor diagnosis | 90.0% (68.3% to 98.8%) | 93.4% (87.4% to 97.1%) |
| Wheezing on ≥2 occasions+doctor diagnosis | 87.0% (89.3% to 98.1%) | 94.9% (89.3% to 98.1%) |
| Ever reported a frequent wheeze+doctor diagnosis | 94.4% (72.7% to 99.9%) | 92.7% (86.6% to 96.6%) |
ALSPAC, Avon Longitudinal Study of Parents and Children; NPV, negative predictive value; PPV, positive predictive value.